Clinical outcomes and costs
| Variable . | T-cell depletion . | Immunosuppressive medication . | P . |
|---|---|---|---|
| N | 48 | 98 | |
| Cumulative incidence of relapse at 1 y | 16% ± 5% | 15% ± 4% | .84 |
| Cumulative incidence of grades II-IV acute graft-versus-host disease at 100 d | 46% ± 7% | 36% ± 5% | .15 |
| Cumulative incidence of extensive chronic graft-versus-host disease at 1 y | 9% ± 4% | 9% ± 3% | .69 |
| Event-free survival at 1 y | 42% ± 8% | 47% ± 5% | .48 |
| Survival at 1 y | 46% ± 8% | 49% ± 5% | .25 |
| Organ toxicity (%) | |||
| Pulmonary | 7 (15) | 27 (28) | .10 |
| Veno-occlusive disease | 4 (8) | 22 (22) | .04 |
| Renal/bladder | 4 (8) | 10 (10) | .99 |
| Infectious | 4 (8) | 11 (11) | .77 |
| Cause of death* (%) | |||
| Relapse | 4 (16) | 19 (31) | .19 |
| Graft-versus-host disease | 3 (12) | 11 (18) | .75 |
| Pulmonary | 11 (44) | 24 (39) | .81 |
| Infection | 8 (32) | 14 (23) | .42 |
| Other | 6 (24) | 15 (24) | .99 |
| Hospital days within first year, median (range) | 34 (19-127) | 46 (18-176) | .0006 |
| Length of initial hospital stay, d (range) | 26 (19-68) | 39 (18-84) | < .0001 |
| Cost of first year, 2000; $ × 1000 median (range) | 113 (44-390) | 155 (67-479) | < .0001 |
| Cost of initial hospitalization, 2000; $ × 1000 median (range) | 86 (37-259) | 139 (56-479) | < .0001 |
| Variable . | T-cell depletion . | Immunosuppressive medication . | P . |
|---|---|---|---|
| N | 48 | 98 | |
| Cumulative incidence of relapse at 1 y | 16% ± 5% | 15% ± 4% | .84 |
| Cumulative incidence of grades II-IV acute graft-versus-host disease at 100 d | 46% ± 7% | 36% ± 5% | .15 |
| Cumulative incidence of extensive chronic graft-versus-host disease at 1 y | 9% ± 4% | 9% ± 3% | .69 |
| Event-free survival at 1 y | 42% ± 8% | 47% ± 5% | .48 |
| Survival at 1 y | 46% ± 8% | 49% ± 5% | .25 |
| Organ toxicity (%) | |||
| Pulmonary | 7 (15) | 27 (28) | .10 |
| Veno-occlusive disease | 4 (8) | 22 (22) | .04 |
| Renal/bladder | 4 (8) | 10 (10) | .99 |
| Infectious | 4 (8) | 11 (11) | .77 |
| Cause of death* (%) | |||
| Relapse | 4 (16) | 19 (31) | .19 |
| Graft-versus-host disease | 3 (12) | 11 (18) | .75 |
| Pulmonary | 11 (44) | 24 (39) | .81 |
| Infection | 8 (32) | 14 (23) | .42 |
| Other | 6 (24) | 15 (24) | .99 |
| Hospital days within first year, median (range) | 34 (19-127) | 46 (18-176) | .0006 |
| Length of initial hospital stay, d (range) | 26 (19-68) | 39 (18-84) | < .0001 |
| Cost of first year, 2000; $ × 1000 median (range) | 113 (44-390) | 155 (67-479) | < .0001 |
| Cost of initial hospitalization, 2000; $ × 1000 median (range) | 86 (37-259) | 139 (56-479) | < .0001 |
All listed causes of death, so total percent exceeds 100%.