RR and AR of second malignancy by initial radiation field (+/− chemotherapy) in 961 patients with more than 10 years of potential follow-up
| . | No. . | PY . | O . | E . | RR . | (95% CI) . | AR . | P . |
|---|---|---|---|---|---|---|---|---|
| Mantle alone | 45 | 541 | 6 | 2.9 | 2.1 | (0.8, 4.6) | 58.1 | .25 |
| MPA/PPA alone | 542 | 8573 | 89 | 21.3 | 4.2 | (3.4, 5.1) | 78.9 | |
| TNI alone9-150 | 78 | 1188 | 14 | 2.8 | 5.1 | (2.8, 8.5) | 94.7 | |
| CT + mantle | 121 | 1346 | 13 | 2.8 | 4.7 | (2.5, 8.0) | 76.0 | .03 |
| CT + MPA/PPA | 128 | 1904 | 27 | 4.6 | 5.9 | (3.9, 8.4) | 117.9 | |
| CT + TNI9-150 | 46 | 776 | 12 | 0.9 | 13.5 | (7.0, 23.5) | 143.1 |
| . | No. . | PY . | O . | E . | RR . | (95% CI) . | AR . | P . |
|---|---|---|---|---|---|---|---|---|
| Mantle alone | 45 | 541 | 6 | 2.9 | 2.1 | (0.8, 4.6) | 58.1 | .25 |
| MPA/PPA alone | 542 | 8573 | 89 | 21.3 | 4.2 | (3.4, 5.1) | 78.9 | |
| TNI alone9-150 | 78 | 1188 | 14 | 2.8 | 5.1 | (2.8, 8.5) | 94.7 | |
| CT + mantle | 121 | 1346 | 13 | 2.8 | 4.7 | (2.5, 8.0) | 76.0 | .03 |
| CT + MPA/PPA | 128 | 1904 | 27 | 4.6 | 5.9 | (3.9, 8.4) | 117.9 | |
| CT + TNI9-150 | 46 | 776 | 12 | 0.9 | 13.5 | (7.0, 23.5) | 143.1 |
One patient who received combined modality therapy received whole brain radiation therapy and was excluded from the analysis.
PY indicates person-years; O, observed; E, expected; RR, relative risk; CI, confidence interval; AR, absolute excess risk; MPA/PPA, mantle and paraaortics/paraaortics and pelvc; TNI, total nodal irradiation; CT, chemotherapy.
P = .019.