RR and AR of second malignancy by follow-up interval in all 1319 patients
| Intervals . | Person-years . | O . | E . | RR . | (95% CI) . | AR . |
|---|---|---|---|---|---|---|
| All sites | ||||||
| 0-5 | 5846 | 24 | 11.0 | 2.2 | (1.4, 3.1) | 22.2 |
| 5-10 | 4303 | 33 | 9.7 | 3.4 | (2.4, 4.7) | 54.2 |
| 10-15 | 3002 | 33 | 8.2 | 4.0 | (2.8, 5.5) | 82.5 |
| 15-20 | 1751 | 46 | 5.9 | 7.8 | (5.8, 10.3) | 229.2 |
| 20+ | 1009 | 45 | 4.1 | 10.9 | (7.8, 14.2) | 404.7 |
| Acute leukemia | ||||||
| 0-5 | 5846 | 11 | 0.09 | 128.0 | (63.9, 229.0) | 18.7 |
| 5-10 | 4303 | 7 | 0.07 | 100.3 | (40.3, 206.6) | 16.1 |
| 10-15 | 3002 | 3 | 0.06 | 52.8 | (10.9, 154.3) | 9.8 |
| 15-20 | 1751 | 0 | 0.04 | 0 | (0.0, 93.8) | − 0.2 |
| 20+ | 1009 | 2 | 0.03 | 74.8 | (9.0, 269.9) | 19.5 |
| NHL | ||||||
| 0-5 | 5846 | 5 | 0.41 | 12.2 | (4.0, 28.5) | 7.9 |
| 5-10 | 4303 | 8 | 0.35 | 22.5 | (9.7, 44.4) | 17.8 |
| 10-15 | 3002 | 2 | 0.31 | 6.4 | (0.8, 23.3) | 5.6 |
| 15-20 | 1751 | 2 | 0.22 | 8.9 | (1.7, 32.2) | 10.1 |
| 20+ | 1009 | 7 | 0.16 | 44.3 | (17.8, 91.3) | 67.8 |
| Solid tumors | ||||||
| 0-5 | 5846 | 7 | 10.5 | 0.7 | (0.3, 1.4) | − 5.9 |
| 5-10 | 4303 | 18 | 9.17 | 2.0 | (1.2, 3.1) | 20.5 |
| 10-15 | 3002 | 27 | 7.81 | 3.5 | (2.3, 4.9) | 63.9 |
| 15-20 | 1751 | 43 | 5.55 | 7.7 | (5.7, 10.3) | 213.9 |
| 20+ | 1009 | 36 | 3.92 | 9.2 | (6.5, 12.4) | 317.8 |
| Breast cancer (females only) | ||||||
| 0-5 | 2640 | 0 | 1.43 | 0 | (0.0, 2.6) | − 5.4 |
| 5-10 | 1962 | 3 | 1.32 | 2.3 | (0.5, 6.6) | 8.5 |
| 10-15 | 1342 | 5 | 1.29 | 3.9 | (1.3, 9.1) | 27.7 |
| 15-20 | 754 | 16 | 1.0 | 16.1 | (9.2, 26.1) | 198.9 |
| 20+ | 421 | 15 | 0.75 | 20.1 | (11.3, 33.2) | 338.4 |
| Lung cancer | ||||||
| 0-5 | 5846 | 0 | 1.19 | 0 | (0.0, 3.1) | − 2.0 |
| 5-10 | 4303 | 4 | 1.04 | 3.8 | (1.0, 9.8) | 6.9 |
| 10-15 | 3002 | 5 | 0.95 | 5.2 | (1.7, 12.2) | 13.5 |
| 15-20 | 1751 | 6 | 0.75 | 8.0 | (2.9, 17.3) | 30.0 |
| 20+ | 1009 | 7 | 0.59 | 11.9 | (4.8, 24.5) | 63.5 |
| GI cancer | ||||||
| 0-5 | 5846 | 4 | 1.62 | 2.5 | (0.7, 6.4) | 4.1 |
| 5-10 | 4303 | 4 | 1.39 | 2.9 | (0.8, 7.4) | 6.1 |
| 10-15 | 3002 | 3 | 1.27 | 2.4 | (0.5, 6.9) | 5.8 |
| 15-20 | 1751 | 7 | 0.97 | 7.2 | (2.9, 14.9) | 34.4 |
| 20+ | 1009 | 6 | 0.72 | 8.3 | (3.1, 18.1) | 52.3 |
| Intervals . | Person-years . | O . | E . | RR . | (95% CI) . | AR . |
|---|---|---|---|---|---|---|
| All sites | ||||||
| 0-5 | 5846 | 24 | 11.0 | 2.2 | (1.4, 3.1) | 22.2 |
| 5-10 | 4303 | 33 | 9.7 | 3.4 | (2.4, 4.7) | 54.2 |
| 10-15 | 3002 | 33 | 8.2 | 4.0 | (2.8, 5.5) | 82.5 |
| 15-20 | 1751 | 46 | 5.9 | 7.8 | (5.8, 10.3) | 229.2 |
| 20+ | 1009 | 45 | 4.1 | 10.9 | (7.8, 14.2) | 404.7 |
| Acute leukemia | ||||||
| 0-5 | 5846 | 11 | 0.09 | 128.0 | (63.9, 229.0) | 18.7 |
| 5-10 | 4303 | 7 | 0.07 | 100.3 | (40.3, 206.6) | 16.1 |
| 10-15 | 3002 | 3 | 0.06 | 52.8 | (10.9, 154.3) | 9.8 |
| 15-20 | 1751 | 0 | 0.04 | 0 | (0.0, 93.8) | − 0.2 |
| 20+ | 1009 | 2 | 0.03 | 74.8 | (9.0, 269.9) | 19.5 |
| NHL | ||||||
| 0-5 | 5846 | 5 | 0.41 | 12.2 | (4.0, 28.5) | 7.9 |
| 5-10 | 4303 | 8 | 0.35 | 22.5 | (9.7, 44.4) | 17.8 |
| 10-15 | 3002 | 2 | 0.31 | 6.4 | (0.8, 23.3) | 5.6 |
| 15-20 | 1751 | 2 | 0.22 | 8.9 | (1.7, 32.2) | 10.1 |
| 20+ | 1009 | 7 | 0.16 | 44.3 | (17.8, 91.3) | 67.8 |
| Solid tumors | ||||||
| 0-5 | 5846 | 7 | 10.5 | 0.7 | (0.3, 1.4) | − 5.9 |
| 5-10 | 4303 | 18 | 9.17 | 2.0 | (1.2, 3.1) | 20.5 |
| 10-15 | 3002 | 27 | 7.81 | 3.5 | (2.3, 4.9) | 63.9 |
| 15-20 | 1751 | 43 | 5.55 | 7.7 | (5.7, 10.3) | 213.9 |
| 20+ | 1009 | 36 | 3.92 | 9.2 | (6.5, 12.4) | 317.8 |
| Breast cancer (females only) | ||||||
| 0-5 | 2640 | 0 | 1.43 | 0 | (0.0, 2.6) | − 5.4 |
| 5-10 | 1962 | 3 | 1.32 | 2.3 | (0.5, 6.6) | 8.5 |
| 10-15 | 1342 | 5 | 1.29 | 3.9 | (1.3, 9.1) | 27.7 |
| 15-20 | 754 | 16 | 1.0 | 16.1 | (9.2, 26.1) | 198.9 |
| 20+ | 421 | 15 | 0.75 | 20.1 | (11.3, 33.2) | 338.4 |
| Lung cancer | ||||||
| 0-5 | 5846 | 0 | 1.19 | 0 | (0.0, 3.1) | − 2.0 |
| 5-10 | 4303 | 4 | 1.04 | 3.8 | (1.0, 9.8) | 6.9 |
| 10-15 | 3002 | 5 | 0.95 | 5.2 | (1.7, 12.2) | 13.5 |
| 15-20 | 1751 | 6 | 0.75 | 8.0 | (2.9, 17.3) | 30.0 |
| 20+ | 1009 | 7 | 0.59 | 11.9 | (4.8, 24.5) | 63.5 |
| GI cancer | ||||||
| 0-5 | 5846 | 4 | 1.62 | 2.5 | (0.7, 6.4) | 4.1 |
| 5-10 | 4303 | 4 | 1.39 | 2.9 | (0.8, 7.4) | 6.1 |
| 10-15 | 3002 | 3 | 1.27 | 2.4 | (0.5, 6.9) | 5.8 |
| 15-20 | 1751 | 7 | 0.97 | 7.2 | (2.9, 14.9) | 34.4 |
| 20+ | 1009 | 6 | 0.72 | 8.3 | (3.1, 18.1) | 52.3 |
O indicates observed; E, expected; RR, relative risk; CI, confidence interval; AR, absolute excess risk; NHL, non-Hodgkin lymphoma; GI, gastrointestinal.