Patient characteristics (n = 48)
| . | Median (range) . | No. (%) . |
|---|---|---|
| Age, y | 62 (44-79) | |
| Sex | — | |
| Male | 33 (69) | |
| Female | 15 (31) | |
| ECOG performance status | — | |
| 0, 1 | 43 (90) | |
| 2 | 5 (10) | |
| WBC count, × 109/L | 35.8 (4-435) | — |
| Hemoglobin level, g/dL | 10.3 (6.4-15.2) | — |
| Platelet count, × 109/L | 64 (4-542) | — |
| β2-microglobulin, mg/dL | 5.2 (2.4-15.8) | — |
| Disease | ||
| CLL | — | 32 (67) |
| CLL/PLL | — | 9 (19) |
| PLL | — | 1 (2) |
| MCL | — | 4 (8) |
| Richter transformation | — | 2 (4) |
| Site of disease | ||
| Peripheral blood | — | 36 |
| Bone marrow | — | 44 |
| Lymph nodes | — | 43 |
| Liver/spleen | — | 14 |
| No. of prior therapies | 4 (1-9) | — |
| Prior exposure | ||
| Rituximab | — | 32 (67) |
| Alemtuzumab | — | 1 (2) |
| Both | — | 4 (8) |
| Rai stage 3 or higher | — | 39 (79) |
| Refractoriness | ||
| Alkylator therapy | — | 25 (52) |
| Fludarabine | — | 26 (54) |
| Both | — | 22 (49) |
| . | Median (range) . | No. (%) . |
|---|---|---|
| Age, y | 62 (44-79) | |
| Sex | — | |
| Male | 33 (69) | |
| Female | 15 (31) | |
| ECOG performance status | — | |
| 0, 1 | 43 (90) | |
| 2 | 5 (10) | |
| WBC count, × 109/L | 35.8 (4-435) | — |
| Hemoglobin level, g/dL | 10.3 (6.4-15.2) | — |
| Platelet count, × 109/L | 64 (4-542) | — |
| β2-microglobulin, mg/dL | 5.2 (2.4-15.8) | — |
| Disease | ||
| CLL | — | 32 (67) |
| CLL/PLL | — | 9 (19) |
| PLL | — | 1 (2) |
| MCL | — | 4 (8) |
| Richter transformation | — | 2 (4) |
| Site of disease | ||
| Peripheral blood | — | 36 |
| Bone marrow | — | 44 |
| Lymph nodes | — | 43 |
| Liver/spleen | — | 14 |
| No. of prior therapies | 4 (1-9) | — |
| Prior exposure | ||
| Rituximab | — | 32 (67) |
| Alemtuzumab | — | 1 (2) |
| Both | — | 4 (8) |
| Rai stage 3 or higher | — | 39 (79) |
| Refractoriness | ||
| Alkylator therapy | — | 25 (52) |
| Fludarabine | — | 26 (54) |
| Both | — | 22 (49) |
WBC indicates white blood cell; CLL, chronic lymphocytic leukemia; PLL, prolymphocytic leukemia; MCL, mantle cell leukemia. — indicates not applicable.