Human inhibitory NK cell receptors
| Receptor . | Ligand specificity . |
|---|---|
| KIR | |
| KIR2DL1 (CD158a) | Group 2 HLA-C Asn77Lys80 (w2, w4, w5, w6, and related alleles) |
| KIR2DL2 (CD158b) | Group 1 HLA-C Ser77Asn80 (w1, w3, w7, w8, and related alleles) |
| KIR2DL3 (CD158b) | Group 1 HLA-C Ser77Asn80 (w1, w3, w7, w8, and related alleles) |
| KIR2DL5 | Unknown |
| KIR3DL1 | HLA-Bw4 |
| KIR3DL2 | HLA-A3, -A11 |
| KIR3DL7 | Unknown |
| C-type lectin receptors | |
| CD94/NKG2A/B* | HLA-E (loaded with HLA-A, -B, -C, -G leader peptides) |
| Immunoglobulinlike transcripts | |
| ILT-2 (LIR-1) | Unknown |
| Others | |
| P75/AIRM | Unknown (sialic acid dependent) |
| IRp60 | Unknown |
| LAIR-1 | Ep-CAM |
| Receptor . | Ligand specificity . |
|---|---|
| KIR | |
| KIR2DL1 (CD158a) | Group 2 HLA-C Asn77Lys80 (w2, w4, w5, w6, and related alleles) |
| KIR2DL2 (CD158b) | Group 1 HLA-C Ser77Asn80 (w1, w3, w7, w8, and related alleles) |
| KIR2DL3 (CD158b) | Group 1 HLA-C Ser77Asn80 (w1, w3, w7, w8, and related alleles) |
| KIR2DL5 | Unknown |
| KIR3DL1 | HLA-Bw4 |
| KIR3DL2 | HLA-A3, -A11 |
| KIR3DL7 | Unknown |
| C-type lectin receptors | |
| CD94/NKG2A/B* | HLA-E (loaded with HLA-A, -B, -C, -G leader peptides) |
| Immunoglobulinlike transcripts | |
| ILT-2 (LIR-1) | Unknown |
| Others | |
| P75/AIRM | Unknown (sialic acid dependent) |
| IRp60 | Unknown |
| LAIR-1 | Ep-CAM |
Asn, asparagine; Lys, lysine; Ser, serine; LAIR, leukocyte-associated immunoglobulinlike receptor; Ep-CAM, epithelial cellular adhesion molecule.134
NKG2A and NKG2B are splice transcripts.