Summary of regulatory responses
| Gene name . | Treatment . | |||||
|---|---|---|---|---|---|---|
| D . | Hfe . | FAC . | Hemin . | SNP . | H2O2 . | |
| HO-1 | ↓ | ↓ | ↑ | ⇈ | ⇈ | ↑ |
| Hsp70D | ⇊ | ⇊ | ↑ | ⇈ | ↓ | — |
| MHsp70 | ↓ | ↓ | ↑ | ↑ | — | — |
| L-fer | ↓ | ↓ | ↑ | ↑ | — | — |
| Gas-3 | ↓ | ↓ | ↑ | ↑ | — | — |
| TfR-1 | ⇈ | ↑ | ↓ | ⇊ | ⇊ | ↑ |
| Hsp105α | ↓ | ↓ | — | ↑ | — | — |
| Mt-2 | — | ↑ | ↓ | ↓ | ↑ | — |
| c-jun | ⇈ | ↑ | — | ↓ | — | — |
| Lysyl oxidase | ⇈ | ↑ | — | ↓ | — | — |
| c-myc | ↓ | — | — | — | — | — |
| Gas-1 | ↓ | — | — | ↑ | — | — |
| DMT-1 | — | — | — | — | ↓ | — |
| Hif-1α | — | — | — | ↓ | — | — |
| Prion | — | — | — | — | ↑ | — |
| Mt-1 | — | — | — | — | ↑ | — |
| HnrnpJKTP | — | — | — | — | ↓ | — |
| Gene name . | Treatment . | |||||
|---|---|---|---|---|---|---|
| D . | Hfe . | FAC . | Hemin . | SNP . | H2O2 . | |
| HO-1 | ↓ | ↓ | ↑ | ⇈ | ⇈ | ↑ |
| Hsp70D | ⇊ | ⇊ | ↑ | ⇈ | ↓ | — |
| MHsp70 | ↓ | ↓ | ↑ | ↑ | — | — |
| L-fer | ↓ | ↓ | ↑ | ↑ | — | — |
| Gas-3 | ↓ | ↓ | ↑ | ↑ | — | — |
| TfR-1 | ⇈ | ↑ | ↓ | ⇊ | ⇊ | ↑ |
| Hsp105α | ↓ | ↓ | — | ↑ | — | — |
| Mt-2 | — | ↑ | ↓ | ↓ | ↑ | — |
| c-jun | ⇈ | ↑ | — | ↓ | — | — |
| Lysyl oxidase | ⇈ | ↑ | — | ↓ | — | — |
| c-myc | ↓ | — | — | — | — | — |
| Gas-1 | ↓ | — | — | ↑ | — | — |
| DMT-1 | — | — | — | — | ↓ | — |
| Hif-1α | — | — | — | ↓ | — | — |
| Prion | — | — | — | — | ↑ | — |
| Mt-1 | — | — | — | — | ↑ | — |
| HnrnpJKTP | — | — | — | — | ↓ | — |
The regulatory profiles of desferrioxamine (D)-treated, HFE-expressing (Hfe), ferric ammonium citrate (FAC)–, hemin-, sodium nitroprusside (SNP)– and H2O2-treated HeLa cells are summarized. All genes that were scored as differentially expressed in the different treatments are listed.
⇊ indicates a more than 3-fold decrease in mRNA levels; ↓, a decrease in mRNA levels between 1.4-fold and 2.9-fold; ⇈, a more than 3-fold increase in mRNA levels; ↑, an increase in mRNA levels between 1.4-fold and 2.9-fold; and —, no significant change in mRNA levels.