Gene expression profiles from desferrioxamine-treated and HFE-expressing HeLa cells
| Gene name . | Expression change . | |
|---|---|---|
| D . | HFE . | |
| HFE | — | +20.0 ± 10.0 |
| TfR-1 | +3.0 ± 2.0 | +2.1 ± 0.3 |
| c-jun | +5.0 ± 2.0 | +1.9 ± 0.4 |
| lysyl oxidase | +5.0 ± 3.0 | +1.8 ± 0.3 |
| Mt-2 | — | +1.6 ± 0.2 |
| HO-1 | −1.8 ± 0.2 | −1.9 ± 0.4 |
| Hsp70D | −4.0 ± 2.0 | −3.4 ± 1.5 |
| Hsp105α | −1.7 ± 0.1 | −2.0 ± 0.3 |
| mHsp70 | −1.5 ± 0.05 | −1.7 ± 0.1 |
| L-Fer | −1.6 ± 0.1 | −2.3 ± 0.8 |
| Gas-3 | −1.7 ± 0.1 | −2.2 ± 0.4 |
| c-myc | −2.0 ± 0.3 | — |
| Gas-1 | −1.7 ± 0.1 | — |
| Gene name . | Expression change . | |
|---|---|---|
| D . | HFE . | |
| HFE | — | +20.0 ± 10.0 |
| TfR-1 | +3.0 ± 2.0 | +2.1 ± 0.3 |
| c-jun | +5.0 ± 2.0 | +1.9 ± 0.4 |
| lysyl oxidase | +5.0 ± 3.0 | +1.8 ± 0.3 |
| Mt-2 | — | +1.6 ± 0.2 |
| HO-1 | −1.8 ± 0.2 | −1.9 ± 0.4 |
| Hsp70D | −4.0 ± 2.0 | −3.4 ± 1.5 |
| Hsp105α | −1.7 ± 0.1 | −2.0 ± 0.3 |
| mHsp70 | −1.5 ± 0.05 | −1.7 ± 0.1 |
| L-Fer | −1.6 ± 0.1 | −2.3 ± 0.8 |
| Gas-3 | −1.7 ± 0.1 | −2.2 ± 0.4 |
| c-myc | −2.0 ± 0.3 | — |
| Gas-1 | −1.7 ± 0.1 | — |
Total RNA derived from HeLa cells treated with 100 μM desferrioxamine (D) for 8 hours or total RNA derived from HeLa cells that express HFE from an inducible transgene was analyzed on the IronChip in comparison with control samples. The average ratios of differentially expressed genes and their standard deviations are shown. — indicates no significant change in mRNA levels.