CHK2 protein expression and gene alterations in non-Hodgkin lymphomas
| Case no. . | Histology . | CHK2 . | Chromosomal imbalances (CGH) . | ATM . | p53 . | |
|---|---|---|---|---|---|---|
| Protein . | Gene . | |||||
| 1022 | LCL | − | GL | 13 | WT | WT |
| 790 | B-MCL | − | GL | 20 | WT | Mut |
| 1016 | LCL | −/+ | GL | 0 | NA | WT |
| 577 | B-MCL | −/+ | GL | 9 | Mut | Del |
| 578 | T-MCL | −/+ | GL | 3 | WT | WT |
| 266 | B-MCL | + | Ile157Thr/GL | 4 | WT | WT |
| Case no. . | Histology . | CHK2 . | Chromosomal imbalances (CGH) . | ATM . | p53 . | |
|---|---|---|---|---|---|---|
| Protein . | Gene . | |||||
| 1022 | LCL | − | GL | 13 | WT | WT |
| 790 | B-MCL | − | GL | 20 | WT | Mut |
| 1016 | LCL | −/+ | GL | 0 | NA | WT |
| 577 | B-MCL | −/+ | GL | 9 | Mut | Del |
| 578 | T-MCL | −/+ | GL | 3 | WT | WT |
| 266 | B-MCL | + | Ile157Thr/GL | 4 | WT | WT |
LCL indicates large cell lymphoma; B-MCL, blastoid mantle cell lymphoma; T-MCL, typical mantle cell lymphoma; Del, homozygous deletion; GL, germ line; WT, wild type; Mut, mutated; NA, not available; −, absence of protein expression; and −/+, protein down-regulation.