Table 1. CHK2 gene alterations and... | American Society of Hematology

Table 1.

CHK2 gene alterations and expression in a series of malignant non-Hodgkin lymphomas

Diagnosis	Gene alterations^1-153	Loss of protein expression^1-153	mRNA expression		Proliferation, Ki-67^*		Chromosomal imbalances, CGH^†
Diagnosis	Gene alterations^1-153	Loss of protein expression^1-153	n	mean ± SD	n	mean ± SD	n	mean ± SD
Chronic lymphocytic leukemia	0/9	0/7	7	0.7 ± 0.3	5	14.0 ± 8.2	2	4 ± 2.8
Richter syndrome	0/4	0/4	3	1.3 ± 0.3	3	44.8 ± 11.9	4	7.2 ± 5.1
Mantle cell lymphoma
Typical	0/14	1/7	7	1.3 ± 0.4	6	13.5 ± 8.1	13	5.5 ± 3.2
Blastoid	1/10^‡	2/7	7	0.9 ± 0.3	7	51.1 ± 28.0	9	9.2 ± 4.7
Large cell lymphoma	0/23	2/34	10	1.2 ± 0.8	9	56.5 ± 30.1	10	3.1 ± 3.9
Total	1/60	5/59	34		30		38

Diagnosis	Gene alterations^1-153	Loss of protein expression^1-153	mRNA expression		Proliferation, Ki-67^*		Chromosomal imbalances, CGH^†
Diagnosis	Gene alterations^1-153	Loss of protein expression^1-153	n	mean ± SD	n	mean ± SD	n	mean ± SD
Chronic lymphocytic leukemia	0/9	0/7	7	0.7 ± 0.3	5	14.0 ± 8.2	2	4 ± 2.8
Richter syndrome	0/4	0/4	3	1.3 ± 0.3	3	44.8 ± 11.9	4	7.2 ± 5.1
Mantle cell lymphoma
Typical	0/14	1/7	7	1.3 ± 0.4	6	13.5 ± 8.1	13	5.5 ± 3.2
Blastoid	1/10^‡	2/7	7	0.9 ± 0.3	7	51.1 ± 28.0	9	9.2 ± 4.7
Large cell lymphoma	0/23	2/34	10	1.2 ± 0.8	9	56.5 ± 30.1	10	3.1 ± 3.9
Total	1/60	5/59	34		30		38

Percent of positive cells.

Comparative genomic hybridization.

Heterozygous Ile157Thr germ line substitution.

Numbers indicated are number of alterations/number of patients examined.