Population frequencies of DNB
| Population . | Phenotype checked* . | Samples tested . | DNB detected, n . | Phenotype frequency among CcDee† . | Phenotype frequency among all phenotypes . | Haplotype frequency . |
|---|---|---|---|---|---|---|
| Switzerland (Lugano) | All D-positive | 500 | 2 | N/A‡ | 1:292 | 1:220 |
| Switzerland (Bern) | CcDee | 693 | 4 | 1:173 | 1:538 | 1:389 |
| Germany (Ulm) | CcDee | 1118 | 2 | 1:559 | 1:1644 | 1:1295 |
| ccDEe (control) | 1010 | 0 | N/A | N/A | N/A | |
| Denmark (Aarhus) | CcDee | 768 | 0 | < 1:2562-153 | < 1:7982-153 | < 1:6052-153 |
| Population . | Phenotype checked* . | Samples tested . | DNB detected, n . | Phenotype frequency among CcDee† . | Phenotype frequency among all phenotypes . | Haplotype frequency . |
|---|---|---|---|---|---|---|
| Switzerland (Lugano) | All D-positive | 500 | 2 | N/A‡ | 1:292 | 1:220 |
| Switzerland (Bern) | CcDee | 693 | 4 | 1:173 | 1:538 | 1:389 |
| Germany (Ulm) | CcDee | 1118 | 2 | 1:559 | 1:1644 | 1:1295 |
| ccDEe (control) | 1010 | 0 | N/A | N/A | N/A | |
| Denmark (Aarhus) | CcDee | 768 | 0 | < 1:2562-153 | < 1:7982-153 | < 1:6052-153 |
Samples were checked for DNB using monoclonal anti-D LOR17-6C7 (Germany and Denmark) and HIRO-7 (Switzerland).
The phenotype frequencies among CcDee were statistically significantly different, assuming that the 500 D-positive samples tested in Ticino corresponded to 187 CcDee samples (P< .023, Fisher exact test; 4 × 2 contingency table).
Not applicable. The frequency among D-positive was 1:250; both carriers were of CcDee phenotype.
Upper limit of the 95% confidence interval according to the Poisson distribution.