Table 3. Time-dependent univariate and... | American Society of Hematology

Table 3.

Time-dependent univariate and multivariate Cox models demonstrating relative risk of leukemic relapse or death according to various risk factors

Characteristic	Samples obtained before intensification therapy				Samples obtained before and after intensification therapy
Characteristic	RR for RFS	P	RR for OS	P	RR for RFS	P	RR for OS	P
Univariate model
Leukemia detectable by flow cytometry	3.33	.001	3.00	.001	4.18	< .0001	3.45	< .0001
Multivariate model
Leukemia detectable by flow cytometry	3.57	.0004	2.75	.007	4.07	< .0001	3.11	< .0001
Age, 0-2 y or 10-21 y	1.68	.096	1.96	.036	1.55	.072	2.26	.002
Sex, female	0.88	.616	0.94	.819	0.89	.600	0.97	.882
Race, black	2.24	.041	1.36	.467	2.01	.035	1.53	.192
Spleen, slightly or greatly enlarged	1.26	.445	0.68	.243	1.20	.480	0.96	.865
Liver, slightly or greatly enlarged	1.19	.613	1.89	.056	0.89	.683	1.34	.279
WBC count ≥ 100	1.23	.618	1.71	.139	1.79	.061	1.59	.126
> 15% marrow blasts by morphology^3-150	^3-151	^3-151	2.58	.091	1.64	.290	2.15	.058

Characteristic	Samples obtained before intensification therapy				Samples obtained before and after intensification therapy
Characteristic	RR for RFS	P	RR for OS	P	RR for RFS	P	RR for OS	P
Univariate model
Leukemia detectable by flow cytometry	3.33	.001	3.00	.001	4.18	< .0001	3.45	< .0001
Multivariate model
Leukemia detectable by flow cytometry	3.57	.0004	2.75	.007	4.07	< .0001	3.11	< .0001
Age, 0-2 y or 10-21 y	1.68	.096	1.96	.036	1.55	.072	2.26	.002
Sex, female	0.88	.616	0.94	.819	0.89	.600	0.97	.882
Race, black	2.24	.041	1.36	.467	2.01	.035	1.53	.192
Spleen, slightly or greatly enlarged	1.26	.445	0.68	.243	1.20	.480	0.96	.865
Liver, slightly or greatly enlarged	1.19	.613	1.89	.056	0.89	.683	1.34	.279
WBC count ≥ 100	1.23	.618	1.71	.139	1.79	.061	1.59	.126
> 15% marrow blasts by morphology^3-150	^3-151	^3-151	2.58	.091	1.64	.290	2.15	.058

RR indicates relative risk.

After first cycle of induction.

Marrow blasts by morphology had 0 variance when added to the RFS multivariate model. This multivariate model does not include bone marrow blasts.