Factors associated with survival after bone marrow transplantation for myelodysplasia in multivariate analysis
| Variables . | Relative risk of death (95% CI) . | P . |
|---|---|---|
| Age, y6-150 | ||
| (1) Younger than 18 | 1.00 | P6-152overall < .0001 |
| (2) 18-30 | 1.7 (0.9-2.8) | P12 = .0650 |
| (3) 31-45 | 2.6 (1.7-4.2) | P13 < .0001 |
| (4) Older than 45 | 2.8 (1.7-4.4) | P14 < .0001 |
| Blasts in bone marrow before transplantation6-151 | ||
| (1) < 5% | 1.00 | P6-152overall = .0002 |
| (2) 5%-20% | 1.7 (1.3-2.9) | P12 = .0005 |
| (3) > 20% | 2.0 (1.4-3.0) | P13 = .0002 |
| (4) Unknown | 1.2 (0.8-1.8) | P14 = .3690 |
| Platelets before transplantation | ||
| (1) ≥ 100 × 109/L < 100 × 109/L | 1.00 | P6-152overall = .0023 |
| (2) First 6 mos after transplantation6-153 | 2.0 (1.3-3.1) | P12 = .0009 |
| (3) > 6 mos after transplantation6-153 | 1.0 (0.6-1.5) | P13 = .8394 |
| (4) Unknown | 1.3 (0.8-2.0) | P14 = .2516 |
| Variables . | Relative risk of death (95% CI) . | P . |
|---|---|---|
| Age, y6-150 | ||
| (1) Younger than 18 | 1.00 | P6-152overall < .0001 |
| (2) 18-30 | 1.7 (0.9-2.8) | P12 = .0650 |
| (3) 31-45 | 2.6 (1.7-4.2) | P13 < .0001 |
| (4) Older than 45 | 2.8 (1.7-4.4) | P14 < .0001 |
| Blasts in bone marrow before transplantation6-151 | ||
| (1) < 5% | 1.00 | P6-152overall = .0002 |
| (2) 5%-20% | 1.7 (1.3-2.9) | P12 = .0005 |
| (3) > 20% | 2.0 (1.4-3.0) | P13 = .0002 |
| (4) Unknown | 1.2 (0.8-1.8) | P14 = .3690 |
| Platelets before transplantation | ||
| (1) ≥ 100 × 109/L < 100 × 109/L | 1.00 | P6-152overall = .0023 |
| (2) First 6 mos after transplantation6-153 | 2.0 (1.3-3.1) | P12 = .0009 |
| (3) > 6 mos after transplantation6-153 | 1.0 (0.6-1.5) | P13 = .8394 |
| (4) Unknown | 1.3 (0.8-2.0) | P14 = .2516 |
P23 = .0176;P24 = .0104;P34 = .7312.
P23 = .3449;P24 = .0764;P34 = .0191.
3 df.
Different relative risks in early and late posttransplantation periods indicate a covariate with nonproportional hazards. Patients with fewer than 100 × 109/L platelets before transplantation have a significantly higher rate of survival than patients with ≥ 100 × 109/L platelets before transplantation in the first 6 months after transplantation; among patients surviving 6 months or more after transplantation, the pretransplantation platelet count has no prognostic importance.
P12 = probability of testing (1) = (2); P13 = probability of testing (1) = (3); P14 = probability of testing (1) = (4).