Factors associated with treatment-related mortality after bone marrow transplantation for myelodysplasia in multivariate analysis
| Variables . | Relative risk (95% CI) . | P . |
|---|---|---|
| Age, y3-150 | ||
| (1) Younger than 18 | 1.00 | P3-152overall < .0001 |
| (2) 18-30 | 2.9 (1.4-6.2) | P12 = .0056 |
| (3) 31-45 | 4.1 (2.0-8.2) | P13 < .0001 |
| (4) Older than 45 | 4.4 (2.1-8.8) | P14 < .0001 |
| Platelets before transplantation3-151 | ||
| (1) ≥ 100 × 109/L < 100 × 109/L | 1.00 | P3-152overall = .0114 |
| (2) First 6 mos after transplantation3-153 | 2.0 (1.3-3.1) | P12 = .0034 |
| (3) > 6 mos after transplantation3-153 | 0.8 (0.4-1.6) | P13 = .5686 |
| (4) Unknown | 1.3 (0.8-2.2) | P14 = .3073 |
| GVHD prophylaxis | ||
| No T-cell depletion | 1.00 | |
| T-cell depletion | 0.6 (0.3-1.0) | P = .0395 |
| Variables . | Relative risk (95% CI) . | P . |
|---|---|---|
| Age, y3-150 | ||
| (1) Younger than 18 | 1.00 | P3-152overall < .0001 |
| (2) 18-30 | 2.9 (1.4-6.2) | P12 = .0056 |
| (3) 31-45 | 4.1 (2.0-8.2) | P13 < .0001 |
| (4) Older than 45 | 4.4 (2.1-8.8) | P14 < .0001 |
| Platelets before transplantation3-151 | ||
| (1) ≥ 100 × 109/L < 100 × 109/L | 1.00 | P3-152overall = .0114 |
| (2) First 6 mos after transplantation3-153 | 2.0 (1.3-3.1) | P12 = .0034 |
| (3) > 6 mos after transplantation3-153 | 0.8 (0.4-1.6) | P13 = .5686 |
| (4) Unknown | 1.3 (0.8-2.2) | P14 = .3073 |
| GVHD prophylaxis | ||
| No T-cell depletion | 1.00 | |
| T-cell depletion | 0.6 (0.3-1.0) | P = .0395 |
P23 = .1180;P24 = .0773;P34 = .7083.
P23 = .0307.
3 df.
Different relative risks in early and late posttransplantation periods indicate a covariate with nonproportional hazards. For example, patients with fewer than 100 × 109/L platelets before transplantation have a significantly higher rate of treatment-related mortality than patients with ≥ 100 × 109/L platelets before transplantation in the first 6 months after transplantation. Among patients surviving 6 months or more after transplantation, the pretransplantation platelet count has no prognostic importance.
P12 = probability of testing (1) = (2); P13 = probability of testing (1) = (3); P14 = probability of testing (1) = (4).