Some unanswered questions for future research
| Quantity . | Quality . |
|---|---|
| For hematologic malignancy outpatients, is there a: | Can immune responders and treatment regimens be identified or stratified? |
| General or | Can special RBC transfusion needs (matching, irradiation, volume reduction) be agreed upon and/or reliably communicated for the sake of consistency and safety? |
| Individually identifiable | At what donor and recipient testing volume (and price point) can higher-fidelity antigen matching achieve RBC seroconversion avoidance and improve patient-reported (and traditional) outcomes? |
| Best RBC trigger and dosing strategy that: | In the PSLR era and in the subset of patients who have already experienced a transfusion reaction, can an alternative (less harmful) premedication regimen achieve reductions in the quantity and/or severity of transfusion reactions? |
| Optimizes quality of life (eg, sense of wellness, best use of time, freedom from fatigue) | |
| Influences bleeding (if at all) | |
| Preserves or extends quantity of life (survival) | |
| Minimizes exposure risks | |
| Saves money/stewards inventory for system-wide sufficiency and improvements |
| Quantity . | Quality . |
|---|---|
| For hematologic malignancy outpatients, is there a: | Can immune responders and treatment regimens be identified or stratified? |
| General or | Can special RBC transfusion needs (matching, irradiation, volume reduction) be agreed upon and/or reliably communicated for the sake of consistency and safety? |
| Individually identifiable | At what donor and recipient testing volume (and price point) can higher-fidelity antigen matching achieve RBC seroconversion avoidance and improve patient-reported (and traditional) outcomes? |
| Best RBC trigger and dosing strategy that: | In the PSLR era and in the subset of patients who have already experienced a transfusion reaction, can an alternative (less harmful) premedication regimen achieve reductions in the quantity and/or severity of transfusion reactions? |
| Optimizes quality of life (eg, sense of wellness, best use of time, freedom from fatigue) | |
| Influences bleeding (if at all) | |
| Preserves or extends quantity of life (survival) | |
| Minimizes exposure risks | |
| Saves money/stewards inventory for system-wide sufficiency and improvements |