The laboratory investigation of a suspected ITP patient
| American Society of Hematology Guidelines9 . | International Consensus Report10 . | McMaster ITP Registry13 . |
|---|---|---|
| CBC | CBC, reticulocytes | CBC, reticulocytes |
| Blood film | Blood film | Blood film |
| HIV | HIV | HIV |
| HCV | HCV | HCV |
| HBV before rituximab | HBV before rituximab | HBV |
| Further tests depend on history, CBC | Quantitative immunoglobulins | Quantitative immunoglobulins |
| DAT | DAT | |
| H pylori (in adults) | H pylori (in adults) | |
| Bone marrow (age ≥60 years) | Bone marrow* | |
| Blood group (Rh) if considering anti-D | Platelet size | |
| Further tests depend on history and CBC | Electrolytes | |
| Creatinine | ||
| Liver enzymes | ||
| Serum protein electrophoresis | ||
| TSH | ||
| ANA | ||
| ACA | ||
| NSI | ||
| Abdominal ultrasound |
| American Society of Hematology Guidelines9 . | International Consensus Report10 . | McMaster ITP Registry13 . |
|---|---|---|
| CBC | CBC, reticulocytes | CBC, reticulocytes |
| Blood film | Blood film | Blood film |
| HIV | HIV | HIV |
| HCV | HCV | HCV |
| HBV before rituximab | HBV before rituximab | HBV |
| Further tests depend on history, CBC | Quantitative immunoglobulins | Quantitative immunoglobulins |
| DAT | DAT | |
| H pylori (in adults) | H pylori (in adults) | |
| Bone marrow (age ≥60 years) | Bone marrow* | |
| Blood group (Rh) if considering anti-D | Platelet size | |
| Further tests depend on history and CBC | Electrolytes | |
| Creatinine | ||
| Liver enzymes | ||
| Serum protein electrophoresis | ||
| TSH | ||
| ANA | ||
| ACA | ||
| NSI | ||
| Abdominal ultrasound |
CBC, complete blood count; HBV, hepatitis B virus; HCV, hepatitis C virus; NSI, nonspecific inhibitor; TSH, thyrotropin.
We perform a bone marrow test if there are unexplained hematological findings, such as macrocytosis, or if the patient has had a poor response to standard therapy.