Table 3.

Changes in heart rate and QT interval by intravenous ATO

Time,
min		Heart rate, bpmQT, ms
Control,
n = 6		0.15 mg/kg,
n = 8		0.45 mg/kg,
n = 7		1.5 mg/kg,
n = 8		Control,
n = 6		0.15 mg/kg,
n = 8		0.45 mg/kg,
n = 7		1.5 mg/kg,
n = 8
0 298.3 ± 13.2 302.4 ± 18.2 308.6 ± 11.7 299.3 ± 10.6 113.5 ± 1.8 112.3 ± 2.1 110.1 ± 1.2 113.6 ± 2.3 
10 308.2 ± 10.9 305.8 ± 11.4 310.2 ± 9.3 310.2 ± 12.4 110.2 ± 1.6 112.9 ± 3.0 113.6 ± 2.2 122.6 ± 1.93-150 
30 297.0 ± 9.4 301.9 ± 13.6 307.5 ± 13.1 298.3 ± 8.5 113.9 ± 2.1 118.1 ± 2.73-150 118.1 ± 1.23-150 129.8 ± 3.0# 
60 302.4 ± 15.1 300.3 ± 11.7 301.4 ± 15.7 307.6 ± 12.3 112.2 ± 2.5 119.0 ± 2.13-150 120.7 ± 3.23-150 130.6 ± 2.8# 
90 308.2 ± 6.9 310.6 ± 9.8 303.6 ± 11.9 296.8 ± 18.3 112.1 ± 1.8 118.2 ± 2.83-150 123.7 ± 2.93-150 138.2 ± 2.7# 
120 301.1 ± 11.3 303.4 ± 12.9 299.8 ± 10.1 300.7 ± 21.8 113.5 ± 3.1 119.5 ± 2.93-150 126.7 ± 4.13-151 139.0 ± 3.8# 
Time,
min		Heart rate, bpmQT, ms
Control,
n = 6		0.15 mg/kg,
n = 8		0.45 mg/kg,
n = 7		1.5 mg/kg,
n = 8		Control,
n = 6		0.15 mg/kg,
n = 8		0.45 mg/kg,
n = 7		1.5 mg/kg,
n = 8
0 298.3 ± 13.2 302.4 ± 18.2 308.6 ± 11.7 299.3 ± 10.6 113.5 ± 1.8 112.3 ± 2.1 110.1 ± 1.2 113.6 ± 2.3 
10 308.2 ± 10.9 305.8 ± 11.4 310.2 ± 9.3 310.2 ± 12.4 110.2 ± 1.6 112.9 ± 3.0 113.6 ± 2.2 122.6 ± 1.93-150 
30 297.0 ± 9.4 301.9 ± 13.6 307.5 ± 13.1 298.3 ± 8.5 113.9 ± 2.1 118.1 ± 2.73-150 118.1 ± 1.23-150 129.8 ± 3.0# 
60 302.4 ± 15.1 300.3 ± 11.7 301.4 ± 15.7 307.6 ± 12.3 112.2 ± 2.5 119.0 ± 2.13-150 120.7 ± 3.23-150 130.6 ± 2.8# 
90 308.2 ± 6.9 310.6 ± 9.8 303.6 ± 11.9 296.8 ± 18.3 112.1 ± 1.8 118.2 ± 2.83-150 123.7 ± 2.93-150 138.2 ± 2.7# 
120 301.1 ± 11.3 303.4 ± 12.9 299.8 ± 10.1 300.7 ± 21.8 113.5 ± 3.1 119.5 ± 2.93-150 126.7 ± 4.13-151 139.0 ± 3.8# 
F3-150

P < .05 versus control.

F3-151

P < .01 versus control.

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