Table 1.

Disease characteristics of 11 renal transplantation patients with PTLD

Patient no.Age/sexDisease siteTime to PTLD, moClonalityImmune suppressionGraft rejectionDuration of response, mo
1 59/F Liver/spleen 13 NA Reduced No 29+ 
2 57/M Kidney/colon 24 Monoclonal Reduced D/C No† NR† 
3 24/M Kidney/LN 16 Monoclonal Reduced Yes 39+ 
4* 39/M Skin 18 NA Reduced No 36+ 
5 77/M Kidney/colon 9 NA Reduced Yes 35+ 
6 44/F Small bowel 94 Monoclonal Reduced No 25‡ 
  Small bowel‡  Monoclonal D/C1-153 Yes  5+ 
7 46/M Liver/spleen 13 Monoclonal Reduced No 28+ 
8 34/M Kidney/LN 8 Biclonal Reduced D/C Yes 29+ 
9 31/M Skin 44 Biclonal Reduced No 17+ 
10 51/M Kidney/spleen 10 Monoclonal Reduced D/C Yes 15+ 
11 57/F Bladder 89 Monoclonal Reduced No 14+ 
Patient no.Age/sexDisease siteTime to PTLD, moClonalityImmune suppressionGraft rejectionDuration of response, mo
1 59/F Liver/spleen 13 NA Reduced No 29+ 
2 57/M Kidney/colon 24 Monoclonal Reduced D/C No† NR† 
3 24/M Kidney/LN 16 Monoclonal Reduced Yes 39+ 
4* 39/M Skin 18 NA Reduced No 36+ 
5 77/M Kidney/colon 9 NA Reduced Yes 35+ 
6 44/F Small bowel 94 Monoclonal Reduced No 25‡ 
  Small bowel‡  Monoclonal D/C1-153 Yes  5+ 
7 46/M Liver/spleen 13 Monoclonal Reduced No 28+ 
8 34/M Kidney/LN 8 Biclonal Reduced D/C Yes 29+ 
9 31/M Skin 44 Biclonal Reduced No 17+ 
10 51/M Kidney/spleen 10 Monoclonal Reduced D/C Yes 15+ 
11 57/F Bladder 89 Monoclonal Reduced No 14+ 

Each PTLD lesion had diffuse large B-cell lymphoma histology.

NA indicates tissue not available for analysis; D/C, discontinued; LN, lymph nodes; NR, no response.

*

Kidney/pancreas transplantation.

†

Patient died 4 weeks after diagnosis of PTLD.

‡

Relapsed PTLD.

F1-153

Patient received rituximab at relapse.

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