Risk factors for IA between days 40 and 100 after transplantation (analysis of corticosteroid therapy)
| . | Controls (n = 1552), no. (%) . | Cases (n = 73), no. (%) . | HR . | 95% CI . |
|---|---|---|---|---|
| Recipient-related factors | ||||
| Age, y | ||||
| Younger than 19 | 249 (16.0) | 8 (11.0) | 1.0 | — |
| 19-40 | 659 (42.5) | 21 (28.8) | — | NS |
| Older than 40 | 644 (41.5) | 44 (60.3) | 3.3 | 1.5-7.1‡ |
| CMV serostatus4-150 | ||||
| D−/R− | 542 (35.2) | 15 (20.6) | 1.0 | — |
| D+/R− | 234 (15.2) | 13 (17.8) | 2.2 | 1.0-4.6‡ |
| D−/R+ | 330 (21.4) | 19 (26.0) | — | NS |
| D+/R+ | 436 (28.3) | 26 (35.6) | — | NS |
| Transplant-related factors (stem cells) cell-depleted/CD34-selected | 56 (3.6) | 8 (11.0) | 2.8 | 1.2-6.1‡ |
| Transplant complications | ||||
| Neutropenia4-151 | — | — | 2.3 | 1.1-5.0‡ |
| CMV disease4-151 | — | — | 15.4 | 7.5-31.74-153 |
| Respiratory virus infection4-151 | — | — | 2.8 | 1.3-5.7‡ |
| Corticosteroids, maximum dose, mg/kg/d4-151 | ||||
| 0 | — | — | 1.0 | — |
| Less than 1.9 | — | — | — | NS |
| 2.0-3.0 | — | — | 8.0 | 2.9-22.54-153 |
| More than 3.0 | — | — | 15.4 | 5.2-45.74-153 |
| . | Controls (n = 1552), no. (%) . | Cases (n = 73), no. (%) . | HR . | 95% CI . |
|---|---|---|---|---|
| Recipient-related factors | ||||
| Age, y | ||||
| Younger than 19 | 249 (16.0) | 8 (11.0) | 1.0 | — |
| 19-40 | 659 (42.5) | 21 (28.8) | — | NS |
| Older than 40 | 644 (41.5) | 44 (60.3) | 3.3 | 1.5-7.1‡ |
| CMV serostatus4-150 | ||||
| D−/R− | 542 (35.2) | 15 (20.6) | 1.0 | — |
| D+/R− | 234 (15.2) | 13 (17.8) | 2.2 | 1.0-4.6‡ |
| D−/R+ | 330 (21.4) | 19 (26.0) | — | NS |
| D+/R+ | 436 (28.3) | 26 (35.6) | — | NS |
| Transplant-related factors (stem cells) cell-depleted/CD34-selected | 56 (3.6) | 8 (11.0) | 2.8 | 1.2-6.1‡ |
| Transplant complications | ||||
| Neutropenia4-151 | — | — | 2.3 | 1.1-5.0‡ |
| CMV disease4-151 | — | — | 15.4 | 7.5-31.74-153 |
| Respiratory virus infection4-151 | — | — | 2.8 | 1.3-5.7‡ |
| Corticosteroids, maximum dose, mg/kg/d4-151 | ||||
| 0 | — | — | 1.0 | — |
| Less than 1.9 | — | — | — | NS |
| 2.0-3.0 | — | — | 8.0 | 2.9-22.54-153 |
| More than 3.0 | — | — | 15.4 | 5.2-45.74-153 |
Calculated on the basis of 1552 evaluable control patients and 73 cases. Hazard ratios (HRs) and 95% confidence intervals (CIs) are shown for all significant variables.
—indicates data not applicable; NS, not significant in the multivariable model.
Either donor or recipient serostatus was not available for 10 patients.
Factors entered into the model as time-dependent covariates.
P ≤ .05.
P ≤ .001.