Relation of AKI during the initial TTP episode to the frequency of new-onset hypertension and death following recovery
Outcome . | Patients (%) . | |
---|---|---|
KDIGO AKI stage 0-1 . | KDIGO AKI stage 2-3 . | |
New-onset hypertension | 10/43 (23) | 6/9 (67) |
Death | 6/52 (12) | 7/14 (50) |
Outcome . | Patients (%) . | |
---|---|---|
KDIGO AKI stage 0-1 . | KDIGO AKI stage 2-3 . | |
New-onset hypertension | 10/43 (23) | 6/9 (67) |
Death | 6/52 (12) | 7/14 (50) |
AKI was calculated by KDIGO criteria. KDIGO stages 0-1: serum creatinine (SCr) increase <2× baseline; stages 3-4: SCr increase ≥2× baseline. These data describe our experience from 1995 to 2015. Among 78 patients, 68 survived their initial episode; 2 patients had been lost to follow-up. Therefore, 66 patients were included in these data (median follow-up, 7 years).32 Fourteen of the 66 patients had hypertension preceding their initial episode of TTP and were therefore not included in the analysis for new-onset hypertension; the median follow-up of the 52 remaining patients was 5.5 years. When each of the 4 individual KDIGO stages was analyzed separately, the frequencies of new-onset hypertension (P = .023) and death (P = .015) were greater among patients with more severe AKI.32