Type of chromosome aberration and type of previously administered chemotherapy in 49 consecutive cases of t-MDS and t-AML from the Copenhagen series3
| . | Alkylating agents without topoisomerase II inhibitors . | Topoisomerase II inhibitors + alkylating agents or cisplatin . | Significance by χ2 test . |
|---|---|---|---|
| Deletion or loss of 5q or 7q, monosomy 5 or monosomy 7 | 20/24 | 12/25 | .02 |
| Balanced translocations to chromosome band 11q23 or 21q22 | 0/24 | 12/25 | .0001 |
| . | Alkylating agents without topoisomerase II inhibitors . | Topoisomerase II inhibitors + alkylating agents or cisplatin . | Significance by χ2 test . |
|---|---|---|---|
| Deletion or loss of 5q or 7q, monosomy 5 or monosomy 7 | 20/24 | 12/25 | .02 |
| Balanced translocations to chromosome band 11q23 or 21q22 | 0/24 | 12/25 | .0001 |