Table 2.

Association of HLA-DR15 with pretreatment variables in NIH MDS patients

HLA typeMyeloblasts more than
5% in bone marrow*,
Coexistent
PNH*
Abnormal
cytogenetics
Hypocellular bone marrow
(less than 30% cellularity)
IPSS low risk
and intermediate-1
Fewer than 6 mo
RBC tx dependence
Age less
than 60 y
DR15-negative, % 15 4.4 38.3 21.7 85.1 43.8 37.5 
DR15-positive, % 2.0 22.2 17.2 34.5 93.1 44.8 48.3 
HLA typeMyeloblasts more than
5% in bone marrow*,
Coexistent
PNH*
Abnormal
cytogenetics
Hypocellular bone marrow
(less than 30% cellularity)
IPSS low risk
and intermediate-1
Fewer than 6 mo
RBC tx dependence
Age less
than 60 y
DR15-negative, % 15 4.4 38.3 21.7 85.1 43.8 37.5 
DR15-positive, % 2.0 22.2 17.2 34.5 93.1 44.8 48.3 

RBC tx indicates red blood cell transfusion.

*

P < .05, χ2 test (univariate analysis).

P < .05, logistic regression (multivariate analysis).

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