Diagnostic criteria for multiple myeloma
| Monoclonal gammopathy of undetermined significance . | Smoldering multiple myeloma . | Active multiple myeloma . |
|---|---|---|
| Monoclonal protein on serum and/or urine electrophoresis <10% clonal PCs No SLiM-CRAB criteria | Monoclonal protein on serum and/or urine electrophoresis >10% clonal PCs No SLiM-CRAB criteria | Clonal BM PC >10% of biopsy-proven bony or extramedullary plasmacytoma along with either ≥1 of the following myeloma-defining events: hypercalcemia: serum Ca >11 mg/dL; renal insufficiency: CrCI <40 mL/min or serum Cr >2 mg/dL; anemia: Hb < 10 g/dL; bone lesions: ≥1 osteolytic lesions on skeletal radiography, CT, or PET CT or ≥1 of the following biomarkers of malignancy: clonal BM PC ≥60%; involved: uninvolved serum free light chain ratio ≥100—>1 focal lesion on MRI studies |
| Monoclonal gammopathy of undetermined significance . | Smoldering multiple myeloma . | Active multiple myeloma . |
|---|---|---|
| Monoclonal protein on serum and/or urine electrophoresis <10% clonal PCs No SLiM-CRAB criteria | Monoclonal protein on serum and/or urine electrophoresis >10% clonal PCs No SLiM-CRAB criteria | Clonal BM PC >10% of biopsy-proven bony or extramedullary plasmacytoma along with either ≥1 of the following myeloma-defining events: hypercalcemia: serum Ca >11 mg/dL; renal insufficiency: CrCI <40 mL/min or serum Cr >2 mg/dL; anemia: Hb < 10 g/dL; bone lesions: ≥1 osteolytic lesions on skeletal radiography, CT, or PET CT or ≥1 of the following biomarkers of malignancy: clonal BM PC ≥60%; involved: uninvolved serum free light chain ratio ≥100—>1 focal lesion on MRI studies |
BM, bone marrow; PC, plasma cell.