Table 1. MCS options for children and... | American Society of Hematology

Table 1.

MCS options for children and adults

Device	Type of flow	Max pump rate (max flow)	Used in children	Used in adults	Survival	Major hemorrhage	Ischemic stroke
Temporary
VA-ECMO pumps⁴	Continuous	(10 L/min)	Yes	Yes	38-68% of ECLS	7-10%*,†	4%
Impella 2.5/CP/5.0^9,10	Continuous	51 000 rpm (2.5 L/min); 46 000 rpm (4.0 L/min); 33 000 rpm (5.0 L/min)	Yes	Yes	25-46% at 1 mo (adults)	8% (adults)	4% (adults)
Impella 2.5/CP/5.0^9,10	Continuous		Yes	Yes	68% at 1 mo (pediatrics)	5% (pediatrics)	2% (pediatrics)
TandemHeart⁸	Continuous	3 000-7 000 rpm (5 L/min)	Yes	Yes	43-47% at 1 mo	42-90%	0%
Long-term
EXCOR¹⁴	Pulsatile	30-120 bpm (3-7.2 L/min depending on pump size)	Yes	No	Median survival 144-174 d	28%-50%†,‡	6-29%
HeartMate II⁶	Continuous, axial	8 000-15 000 rpm (3-10 L/min)	Yes, adolescents	Yes	90% at 6 mo	14-15% at 6 mo	6% at 6 mo
HVAD¹⁶	Continuous, centrifugal	2 400-3 200 rpm (10 L/min)	Yes, adolescents	Yes	96% at 6 mo	10-14% at 6 mo	7% at 6 mo
HeartMate 3⁶	Continuous, centrifugal	3 000-9 000 rpm (10 L/min)	NR	Yes	91% at 6 mo	10-16% at 6 mo	5% at 6 mo
Syncardia TAH¹²	Pulsatile	125 bpm (7-9 L/min)	Yes, adolescents	Yes	68% to transplant	25% at 1 mo	5% at 1 mo

Device	Type of flow	Max pump rate (max flow)	Used in children	Used in adults	Survival	Major hemorrhage	Ischemic stroke
Temporary
VA-ECMO pumps⁴	Continuous	(10 L/min)	Yes	Yes	38-68% of ECLS	7-10%*,†	4%
Impella 2.5/CP/5.0^9,10	Continuous	51 000 rpm (2.5 L/min); 46 000 rpm (4.0 L/min); 33 000 rpm (5.0 L/min)	Yes	Yes	25-46% at 1 mo (adults)	8% (adults)	4% (adults)
Impella 2.5/CP/5.0^9,10	Continuous		Yes	Yes	68% at 1 mo (pediatrics)	5% (pediatrics)	2% (pediatrics)
TandemHeart⁸	Continuous	3 000-7 000 rpm (5 L/min)	Yes	Yes	43-47% at 1 mo	42-90%	0%
Long-term
EXCOR¹⁴	Pulsatile	30-120 bpm (3-7.2 L/min depending on pump size)	Yes	No	Median survival 144-174 d	28%-50%†,‡	6-29%
HeartMate II⁶	Continuous, axial	8 000-15 000 rpm (3-10 L/min)	Yes, adolescents	Yes	90% at 6 mo	14-15% at 6 mo	6% at 6 mo
HVAD¹⁶	Continuous, centrifugal	2 400-3 200 rpm (10 L/min)	Yes, adolescents	Yes	96% at 6 mo	10-14% at 6 mo	7% at 6 mo
HeartMate 3⁶	Continuous, centrifugal	3 000-9 000 rpm (10 L/min)	NR	Yes	91% at 6 mo	10-16% at 6 mo	5% at 6 mo
Syncardia TAH¹²	Pulsatile	125 bpm (7-9 L/min)	Yes, adolescents	Yes	68% to transplant	25% at 1 mo	5% at 1 mo

bpm, beats per minute; ECLS, extracorporeal life support; ECMO, extracorporeal membrane oxygenation; Max, maximum; NR, not reported; rpm, revolutions per minute.

Percentage of reported events.

†

Gastrointestinal and intracranial hemorrhage.

‡

Chest reexploration and intracranial.

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