Comparison of HLA-DRB1/-DQB1 frequencies of ITP patients and controls and relationship with Helicobacter pyloriinfection
| HLA class II alleles . | ITP patients (%), n = 39 . | Controls (%), n = 150 . | P* . | ITP patients (%), n = 39 . | ||
|---|---|---|---|---|---|---|
| H pylori+, n = 24 . | H pylori−, n = 15 . | P† . | ||||
| DRB1 | ||||||
| *01 | 8 (20.5) | 32 (21.3) | NS | 5 (20.8) | 3 (20.0) | NS |
| *15 | 7 (17.9) | 30 (20.0) | NS | 3 (12.5) | 4 (26.7) | NS |
| *16 | 5 (12.8) | 12 (10.2) | NS | 2 (8.3) | 3 (20.0) | NS |
| *03 | 10 (25.6) | 28 (18.6) | NS | 3 (12.5) | 7 (46.7) | .01 |
| *04 | 6 (15.4) | 21 (14.0) | NS | 4 (16.7) | 2 (13.3) | NS |
| *11 | 12 (30.8) | 68 (45.3) | .04 | 10 (41.7) | 2 (13.3) | .03 |
| *12 | 0 | 4 (2.6) | NS | 0 | 0 | — |
| *13 | 6 (15.4) | 28 (18.6) | NS | 4 (16.7) | 2 (13.3) | NS |
| *14 | 6 (15.4) | 15 (10.0) | NS | 6 (25.0) | 0 | .02 |
| *07 | 9 (23.1) | 26 (17.3) | NS | 6 (25.0) | 3 (20.0) | NS |
| *08 | 3 (7.7) | 6 (4.0) | NS | 2 (8.3) | 1 (6.7) | NS |
| *0910 | 0 | 2 (1.3) | NS | 0 | 0 | — |
| *1001 | 0 | 6 (4.0) | NS | 0 | 0 | — |
| DQB1 | ||||||
| *02 | 17 (43.6) | 48 (32.0) | NS | 9 (37.5) | 8 (33.3) | NS |
| *03 | 17 (43.6) | 94 (62.6) | .03 | 14 (58.3) | 3 (20.0) | .02 |
| *04 | 3 (7.7) | 7 (4.6) | NS | 2 (8.3) | 1 (6.7) | NS |
| *05 | 17 (43.6) | 66 (44.0) | NS | 11 (45.8) | 6 (40.0) | NS |
| *06 | 10 (25.6) | 50 (33.3) | NS | 5 (20.8) | 5 (33.3) | NS |
| HLA class II alleles . | ITP patients (%), n = 39 . | Controls (%), n = 150 . | P* . | ITP patients (%), n = 39 . | ||
|---|---|---|---|---|---|---|
| H pylori+, n = 24 . | H pylori−, n = 15 . | P† . | ||||
| DRB1 | ||||||
| *01 | 8 (20.5) | 32 (21.3) | NS | 5 (20.8) | 3 (20.0) | NS |
| *15 | 7 (17.9) | 30 (20.0) | NS | 3 (12.5) | 4 (26.7) | NS |
| *16 | 5 (12.8) | 12 (10.2) | NS | 2 (8.3) | 3 (20.0) | NS |
| *03 | 10 (25.6) | 28 (18.6) | NS | 3 (12.5) | 7 (46.7) | .01 |
| *04 | 6 (15.4) | 21 (14.0) | NS | 4 (16.7) | 2 (13.3) | NS |
| *11 | 12 (30.8) | 68 (45.3) | .04 | 10 (41.7) | 2 (13.3) | .03 |
| *12 | 0 | 4 (2.6) | NS | 0 | 0 | — |
| *13 | 6 (15.4) | 28 (18.6) | NS | 4 (16.7) | 2 (13.3) | NS |
| *14 | 6 (15.4) | 15 (10.0) | NS | 6 (25.0) | 0 | .02 |
| *07 | 9 (23.1) | 26 (17.3) | NS | 6 (25.0) | 3 (20.0) | NS |
| *08 | 3 (7.7) | 6 (4.0) | NS | 2 (8.3) | 1 (6.7) | NS |
| *0910 | 0 | 2 (1.3) | NS | 0 | 0 | — |
| *1001 | 0 | 6 (4.0) | NS | 0 | 0 | — |
| DQB1 | ||||||
| *02 | 17 (43.6) | 48 (32.0) | NS | 9 (37.5) | 8 (33.3) | NS |
| *03 | 17 (43.6) | 94 (62.6) | .03 | 14 (58.3) | 3 (20.0) | .02 |
| *04 | 3 (7.7) | 7 (4.6) | NS | 2 (8.3) | 1 (6.7) | NS |
| *05 | 17 (43.6) | 66 (44.0) | NS | 11 (45.8) | 6 (40.0) | NS |
| *06 | 10 (25.6) | 50 (33.3) | NS | 5 (20.8) | 5 (33.3) | NS |