Summary of the PML/RARα mutations identified in ATRA-resistant APL cell lines (numbers 1-6) and patients in relapse (numbers 7-17)
| Cell line/patient in relapse (reference citation) . | Mutations (amino acid) . | Location . |
|---|---|---|
| 1. UF-1 (Takayama et al41) | Arg 276 Trp | H5-6 |
| 2. NB4-R1 (Nason-Burchenal et al38) | Phe 286 deletion | H5-6 |
| 3. NB4-MR4 (Shao et al36 ) | Leu 398 Pro | H11 |
| 4. NB4/RA (Kitamura et al37) | Pro 407 Leu | H11-12 |
| 5. NB4-MRA1 (Côté et al, current study) | Ile 410 Thr | H12 |
| 6. NB4-R2 (Duprez et al39) | Gln 411 stop codon | H12 |
| 7. Case 7 (Zhou et al45) | Lys 207 Asn | H1-H3 |
| 8. Case 1 (Imaizumi et al42); patient 1 (Marasca et al43); case 8 (Zhou et al45) | Arg 272 Gln | H5 |
| 9. Patient 1 (Côté et al, current study); patient 2 (Marasca et al43) | Arg 276 Trp | H5-6 |
| 10. Patients 1 and 2 (Marasca et al44) | Arg 276 Gln | H5-6 |
| 11. Case 6 (Zhou et al45) | Gly 289 Arg | H5-6 |
| 12. Case 14 (Ding et al31) | Leu 290 Val | H5-6 |
| 13. Case 4 (Zhou et al45) | Arg 294 Trp | H6 |
| 14. Case 2 (Imaizumi et al42) | Met 297 Leu | H6 |
| 15. Case 17 (Ding et al31) | Arg 394 Trp | H11 |
| 16. Case 1 (Zhou et al45) | Pro 407 Ser | H11-12 |
| 17. Case 9 (Ding et al31) | Met 413 Thr | H12 |
| Cell line/patient in relapse (reference citation) . | Mutations (amino acid) . | Location . |
|---|---|---|
| 1. UF-1 (Takayama et al41) | Arg 276 Trp | H5-6 |
| 2. NB4-R1 (Nason-Burchenal et al38) | Phe 286 deletion | H5-6 |
| 3. NB4-MR4 (Shao et al36 ) | Leu 398 Pro | H11 |
| 4. NB4/RA (Kitamura et al37) | Pro 407 Leu | H11-12 |
| 5. NB4-MRA1 (Côté et al, current study) | Ile 410 Thr | H12 |
| 6. NB4-R2 (Duprez et al39) | Gln 411 stop codon | H12 |
| 7. Case 7 (Zhou et al45) | Lys 207 Asn | H1-H3 |
| 8. Case 1 (Imaizumi et al42); patient 1 (Marasca et al43); case 8 (Zhou et al45) | Arg 272 Gln | H5 |
| 9. Patient 1 (Côté et al, current study); patient 2 (Marasca et al43) | Arg 276 Trp | H5-6 |
| 10. Patients 1 and 2 (Marasca et al44) | Arg 276 Gln | H5-6 |
| 11. Case 6 (Zhou et al45) | Gly 289 Arg | H5-6 |
| 12. Case 14 (Ding et al31) | Leu 290 Val | H5-6 |
| 13. Case 4 (Zhou et al45) | Arg 294 Trp | H6 |
| 14. Case 2 (Imaizumi et al42) | Met 297 Leu | H6 |
| 15. Case 17 (Ding et al31) | Arg 394 Trp | H11 |
| 16. Case 1 (Zhou et al45) | Pro 407 Ser | H11-12 |
| 17. Case 9 (Ding et al31) | Met 413 Thr | H12 |
Numbers 5 and 9 indicate the PML/RARα mutations identified and characterized in the current study. Numbers 1 to 17 correspond to numbers 1 to 17 in Figure 1B.