Changes in organ function, mRSS, and mHAQ-DI after HDIT
| Parameter . | Months after HDIT . | No. patients . | Median difference from baseline . | P . |
|---|---|---|---|---|
| mRSS | 3 | 15 | − 7 (1 to − 25) | .002 |
| 12 | 12 | − 13 (− 8 to − 19) | .0005 | |
| 24 | 5 | − 19 (− 10 to − 32) | .06 | |
| 36 | 3 | − 21 (− 17 to − 37) | .25 | |
| mHAQ-DI | 3 | 14 | − 1.0 (0 to − 2) | .001 |
| 12 | 11 | − 1.675 (0 to − 2.26) | .002 | |
| 24 | 5 | − 1.875 (− .125 to − 2.01) | .06 | |
| 36 | 3 | − 2.01 (− 2 to − 2.125) | .25 | |
| Serum creatinine | 3 | 15 | 0.1 (− 0.1 to 0.6) | .02 |
| 12 | 11 | 0.1 (− 0.1 to 0.8) | .02 | |
| 24 | 5 | 0.3 (0.2 to 0.7) | .06 | |
| 36 | 2 | 0.5 (0.2 to 0.8) | .50 | |
| DLCO | 3 | 15 | − 11 (− 32 to 3) | .001 |
| 12 | 12 | − 5 (− 26 to 7) | .11 | |
| 24 | 5 | − 4 (− 22 to 10) | .88 | |
| 36 | 3 | 4 (− 28 to 12) | 1.0 | |
| FVC | 3 | 16 | 1 (− 16 to 7) | .87 |
| 12 | 12 | 4 (− 12 to 13) | .10 | |
| 24 | 5 | 3 (− 2 to 16) | .19 | |
| 36 | 3 | − 2 (− 17 to 24) | 1.0 | |
| LVEF | 3 | 12 | − 2 (− 17 to 5) | .02 |
| 12 | 8 | − 0.5 (− 12 to 5) | .81 | |
| 24 | 2 | − 2.5 (− 6 to 1) | 1.0 | |
| 36 | 2 | 0 (− 3 to 3) | 1.0 |
| Parameter . | Months after HDIT . | No. patients . | Median difference from baseline . | P . |
|---|---|---|---|---|
| mRSS | 3 | 15 | − 7 (1 to − 25) | .002 |
| 12 | 12 | − 13 (− 8 to − 19) | .0005 | |
| 24 | 5 | − 19 (− 10 to − 32) | .06 | |
| 36 | 3 | − 21 (− 17 to − 37) | .25 | |
| mHAQ-DI | 3 | 14 | − 1.0 (0 to − 2) | .001 |
| 12 | 11 | − 1.675 (0 to − 2.26) | .002 | |
| 24 | 5 | − 1.875 (− .125 to − 2.01) | .06 | |
| 36 | 3 | − 2.01 (− 2 to − 2.125) | .25 | |
| Serum creatinine | 3 | 15 | 0.1 (− 0.1 to 0.6) | .02 |
| 12 | 11 | 0.1 (− 0.1 to 0.8) | .02 | |
| 24 | 5 | 0.3 (0.2 to 0.7) | .06 | |
| 36 | 2 | 0.5 (0.2 to 0.8) | .50 | |
| DLCO | 3 | 15 | − 11 (− 32 to 3) | .001 |
| 12 | 12 | − 5 (− 26 to 7) | .11 | |
| 24 | 5 | − 4 (− 22 to 10) | .88 | |
| 36 | 3 | 4 (− 28 to 12) | 1.0 | |
| FVC | 3 | 16 | 1 (− 16 to 7) | .87 |
| 12 | 12 | 4 (− 12 to 13) | .10 | |
| 24 | 5 | 3 (− 2 to 16) | .19 | |
| 36 | 3 | − 2 (− 17 to 24) | 1.0 | |
| LVEF | 3 | 12 | − 2 (− 17 to 5) | .02 |
| 12 | 8 | − 0.5 (− 12 to 5) | .81 | |
| 24 | 2 | − 2.5 (− 6 to 1) | 1.0 | |
| 36 | 2 | 0 (− 3 to 3) | 1.0 |
mRSS indicated modified Rodnan skin score expressed as points on a scale of 0-51. mHAQ-DI expressed as points on a scale of 0-3. A baseline mHAQ-DI score was not obtained on patient 13. Serum creatinine was expressed in μg/dL. Carbon monoxide diffusing capacity was corrected for hemoglobin; percentage predicted. Forced vital capacity, percentage of predicted. Left ventricular ejection fraction, percentage.