WHO classification of acute myeloid leukemia
Acute myeloid leukemia with recurrent genetic abnormalities |
Acute myeloid leukemia with t(8;21)(q22;q22), (AML1/ETO) |
Acute myeloid leukemia with abnormal bone marrow eosinophils and inv(16)(p13q22) or t(16;16)(p13;q22), (CBFβ/MYH11) |
Acute promyelocytic leukemia with t(15;17)(q22;q12), (PML/RARα) and variants |
Acute myeloid leukemia with 11q23 (MLL) abnormalities |
Acute myeloid leukemia with multilineage dysplasia |
Following MDS or MDS/MPD |
Without antecedent MDS or MDS/MPD, but with dysplasia in at least 50% of cells in 2 or more myeloid lineages |
Acute myeloid leukemia and myelodysplastic syndromes, therapy related |
Alkylating agent/radiation–related type |
Topoisomerase II inhibitor–related type (some may be lymphoid) |
Others |
Acute myeloid leukemia, not otherwise categorized |
Classify as: |
Acute myeloid leukemia, minimally differentiated |
Acute myeloid leukemia without maturation |
Acute myeloid leukemia with maturation |
Acute myelomonocytic leukemia |
Acute monoblastic/acute monocytic leukemia |
Acute erythroid leukemia (erythroid/myeloid and pure erythroleukemia) |
Acute megakaryoblastic leukemia |
Acute basophilic leukemia |
Acute panmyelosis with myelofibrosis |
Myeloid sarcoma |
Acute myeloid leukemia with recurrent genetic abnormalities |
Acute myeloid leukemia with t(8;21)(q22;q22), (AML1/ETO) |
Acute myeloid leukemia with abnormal bone marrow eosinophils and inv(16)(p13q22) or t(16;16)(p13;q22), (CBFβ/MYH11) |
Acute promyelocytic leukemia with t(15;17)(q22;q12), (PML/RARα) and variants |
Acute myeloid leukemia with 11q23 (MLL) abnormalities |
Acute myeloid leukemia with multilineage dysplasia |
Following MDS or MDS/MPD |
Without antecedent MDS or MDS/MPD, but with dysplasia in at least 50% of cells in 2 or more myeloid lineages |
Acute myeloid leukemia and myelodysplastic syndromes, therapy related |
Alkylating agent/radiation–related type |
Topoisomerase II inhibitor–related type (some may be lymphoid) |
Others |
Acute myeloid leukemia, not otherwise categorized |
Classify as: |
Acute myeloid leukemia, minimally differentiated |
Acute myeloid leukemia without maturation |
Acute myeloid leukemia with maturation |
Acute myelomonocytic leukemia |
Acute monoblastic/acute monocytic leukemia |
Acute erythroid leukemia (erythroid/myeloid and pure erythroleukemia) |
Acute megakaryoblastic leukemia |
Acute basophilic leukemia |
Acute panmyelosis with myelofibrosis |
Myeloid sarcoma |