Primary structure of CMV vaccine peptides
| Peptide . | Lipid molecule(s) . | Adapter sequence . | THtype . | TH epitope sequence . | Linker sequence . | CMV CTL epitope . | Carboxyl terminus . | HLA restriction . |
|---|---|---|---|---|---|---|---|---|
| K25V | None | -K-S-S- | PADRE | -A-K-X*-V-A-A-W-T-L-K-A-A-A- | None | -N-L-V-P-M-V-A-T-V- | OH | A*0201 |
| KTet830V | None | -K-S-S- | Tetanus | -Q-Y-I-K-A-N-S-K-F-I-G-I-T-E- | -A-A-A- | -N-L-V-P-M-V-A-T-V- | OH | A*0201 |
| Tet639V | None | None | Tetanus | -V-S-T-I-V-P-Y-I-G-P-A-L-N-I- | -A-A-A- | -N-L-V-P-M-V-A-T-V- | OH | A*0201 |
| Peptide . | Lipid molecule(s) . | Adapter sequence . | THtype . | TH epitope sequence . | Linker sequence . | CMV CTL epitope . | Carboxyl terminus . | HLA restriction . |
|---|---|---|---|---|---|---|---|---|
| K25V | None | -K-S-S- | PADRE | -A-K-X*-V-A-A-W-T-L-K-A-A-A- | None | -N-L-V-P-M-V-A-T-V- | OH | A*0201 |
| KTet830V | None | -K-S-S- | Tetanus | -Q-Y-I-K-A-N-S-K-F-I-G-I-T-E- | -A-A-A- | -N-L-V-P-M-V-A-T-V- | OH | A*0201 |
| Tet639V | None | None | Tetanus | -V-S-T-I-V-P-Y-I-G-P-A-L-N-I- | -A-A-A- | -N-L-V-P-M-V-A-T-V- | OH | A*0201 |
The sequences of 3 fusion peptides are shown. The derivation of the PADRE TH epitope peptide can be found in Alexander et al,38 Tet830–843 peptide is discussed in Livingston et al,21 Tet639–652 in Reece et al,71 and the A*0201 CMV CTL epitope is discussed in Longmate et al.4 X
indicates cyclohexyl-alanine.