Characteristics and outcomes of patients with adenovirus infections
| UPN . | Age/ sex . | Type of transplantation . | Alemtuzumab dose, mg . | Onset of infection, d . | Sites . | Lymphocytes/ CD4+ T cells/mm3 . | GVHD grade . | Blood PCR . | CyA/ steroid . | Adenovirus disease . | Antiviral . | Other virus infection, non-CMV . | Outcome of adenovirus infection . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 43/M | UD CMT | 100 | 202 | Stool, throat | 100/nd | 3 | Pos | C/C | Liver (def) | Ribavirin | HSV | Died; adeno hepatitis |
| 2 | 50/F | MSD NMT | 100 | 105 | Stool | 290/nd | 0 | Neg | W/− | Gut (prob) | No | HSV | Improved |
| 3 | 38/F | MSD NMT | 100 | 15 | Stool, urine | 480/nd | 0 | Neg | W/Ü+ DLI) | None | No | Polyoma | Improved |
| 4 | 33/M | UD CMT | 100 | 93 | Stool | 100/nd | 0 | nd | C/− | Pneumonia/ MOF (prob) | Ribavirin | RSV, Infl A | Died; viral pneumonia/ MOF |
| 5 | 18/M | UD NMT | 100 | 90 | Stool | 460/180 | 0 | nd | W/− | None | No | None | Improved |
| 6 | 36/M | MSD NMT | 100 | 126 | Stool, throat | 800/160 | 0 | Neg | −/Ü+ DLI) | None | No | Polyoma, RSV, PIV | Improved |
| 7 | 26/M | UD CMT | 20 | 120 | Stool | 900/230 | 0 | Neg | −/− | None | No | PIV | Improved |
| 8 | 22/F | MSD NMT | 100 | 19 | Stool, urine | 0/0 | 0 | Pos | C/− | Liver (def) | Ribavirin | None | Died; adeno hepatitis |
| 9 | 46/M | MSD CMT | 20 | 20 | Stool | 120/50 | 0 | Neg | W/− | None | No | None | Improved |
| 10 | 37/M | MSD NMT | 100 | 135 | Stool | 480/150 | 0 | Neg | −/− | None | No | Polyoma | Improved |
| 11 | 50/F | MSD NMT | 100 | 113 | Stool | 410/90 | 0 | Neg | −/− | None | No | HZV, PIV, Infl B | Improved |
| 12 | 47/M | MSD NMT | 20 | 90 | Stool | 330/160 | 0 | Neg | W/− | None | No | None | Improved |
| 13 | 52/M | UD NMT | 100 | 90 | Stool, throat | 210/30 | 0 | Neg | W/− | Upper respiratory (def) | No | HZV | Improved |
| 14 | 22/F | UD CMT | 50 | 187 | Stool | 250/90 | 3 | Neg | R/W | Gut (prob) | Cidofovir IVIg | HSV | Cleared adeno, died; CMV pneumonia |
| 15 | 39/M | UD NMT | 100 | 88 | Stool | 420/100 | 2 | Neg | R/W | None | No | HSV | Improved |
| UPN . | Age/ sex . | Type of transplantation . | Alemtuzumab dose, mg . | Onset of infection, d . | Sites . | Lymphocytes/ CD4+ T cells/mm3 . | GVHD grade . | Blood PCR . | CyA/ steroid . | Adenovirus disease . | Antiviral . | Other virus infection, non-CMV . | Outcome of adenovirus infection . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 43/M | UD CMT | 100 | 202 | Stool, throat | 100/nd | 3 | Pos | C/C | Liver (def) | Ribavirin | HSV | Died; adeno hepatitis |
| 2 | 50/F | MSD NMT | 100 | 105 | Stool | 290/nd | 0 | Neg | W/− | Gut (prob) | No | HSV | Improved |
| 3 | 38/F | MSD NMT | 100 | 15 | Stool, urine | 480/nd | 0 | Neg | W/Ü+ DLI) | None | No | Polyoma | Improved |
| 4 | 33/M | UD CMT | 100 | 93 | Stool | 100/nd | 0 | nd | C/− | Pneumonia/ MOF (prob) | Ribavirin | RSV, Infl A | Died; viral pneumonia/ MOF |
| 5 | 18/M | UD NMT | 100 | 90 | Stool | 460/180 | 0 | nd | W/− | None | No | None | Improved |
| 6 | 36/M | MSD NMT | 100 | 126 | Stool, throat | 800/160 | 0 | Neg | −/Ü+ DLI) | None | No | Polyoma, RSV, PIV | Improved |
| 7 | 26/M | UD CMT | 20 | 120 | Stool | 900/230 | 0 | Neg | −/− | None | No | PIV | Improved |
| 8 | 22/F | MSD NMT | 100 | 19 | Stool, urine | 0/0 | 0 | Pos | C/− | Liver (def) | Ribavirin | None | Died; adeno hepatitis |
| 9 | 46/M | MSD CMT | 20 | 20 | Stool | 120/50 | 0 | Neg | W/− | None | No | None | Improved |
| 10 | 37/M | MSD NMT | 100 | 135 | Stool | 480/150 | 0 | Neg | −/− | None | No | Polyoma | Improved |
| 11 | 50/F | MSD NMT | 100 | 113 | Stool | 410/90 | 0 | Neg | −/− | None | No | HZV, PIV, Infl B | Improved |
| 12 | 47/M | MSD NMT | 20 | 90 | Stool | 330/160 | 0 | Neg | W/− | None | No | None | Improved |
| 13 | 52/M | UD NMT | 100 | 90 | Stool, throat | 210/30 | 0 | Neg | W/− | Upper respiratory (def) | No | HZV | Improved |
| 14 | 22/F | UD CMT | 50 | 187 | Stool | 250/90 | 3 | Neg | R/W | Gut (prob) | Cidofovir IVIg | HSV | Cleared adeno, died; CMV pneumonia |
| 15 | 39/M | UD NMT | 100 | 88 | Stool | 420/100 | 2 | Neg | R/W | None | No | HSV | Improved |
UPN indicates unique patient number; CyA, cyclosporin A; M, male; UD, unrelated donor; CMT, conventional myeloablative transplantation; nd, not done; C, continued; def, definite; HSV, herpes simplex virus; F, female; MSD, matched sibling donor; NMT, nonmyeloablative transplantation; W, withdrawn; prob, probable; MOF, multiorgan failure; RSV, respiratory syncytial virus; Infl, influenza; PIV, parainfluenza virus; HZV, herpes zoster virus; R, reduced; and IVIg, intravenous immunoglobulin.