Characteristics of MDS in children and adults
| Characteristic . | Children . | Adults . |
|---|---|---|
| Annual incidence per million | 1-2 | 40 |
| Associated abnormalities | 1/3 | <5% |
| Morphologic groups | ||
| Refractory anemia with ringed sideroblasts | <2% | 25% |
| Hypoplastic MDS | Common | Rare |
| Abnormal cytogenetics | 60% | 40% |
| −7/del(7q) | 30%-40% | 10% |
| −5/del(5q) | 1%-2% | 20% |
| Hypermethylation | >50% | >50% |
| Spliceosomal gene aberration | <2% | Common |
| Aim of treatment | Curative | Palliative |
| Characteristic . | Children . | Adults . |
|---|---|---|
| Annual incidence per million | 1-2 | 40 |
| Associated abnormalities | 1/3 | <5% |
| Morphologic groups | ||
| Refractory anemia with ringed sideroblasts | <2% | 25% |
| Hypoplastic MDS | Common | Rare |
| Abnormal cytogenetics | 60% | 40% |
| −7/del(7q) | 30%-40% | 10% |
| −5/del(5q) | 1%-2% | 20% |
| Hypermethylation | >50% | >50% |
| Spliceosomal gene aberration | <2% | Common |
| Aim of treatment | Curative | Palliative |