Analysis of hydroxyurea sensitivity and susceptibility to Friend erythroleukemia in C57BL/6J, BALB/cJ, and 129P3 mice
| Strain . | Genotype . | Killed by hydroxyurea, % . | Friend virus susceptibility (increase in spleen weight) . |
|---|---|---|---|
| C57BL/6J | Fv2rr | 16.2 ± 0.3 | Resistant (1.4×) |
| BALB/cJ | Fv2ss | 66.5 ± 0.2 | Sensitive (20.2×) |
| 129P3 | Fv2ss | 12.4 ± 0.4 | Sensitive (4.0×) |
| Strain . | Genotype . | Killed by hydroxyurea, % . | Friend virus susceptibility (increase in spleen weight) . |
|---|---|---|---|
| C57BL/6J | Fv2rr | 16.2 ± 0.3 | Resistant (1.4×) |
| BALB/cJ | Fv2ss | 66.5 ± 0.2 | Sensitive (20.2×) |
| 129P3 | Fv2ss | 12.4 ± 0.4 | Sensitive (4.0×) |
For all strains, more than 75% of CFU-Es were killed by hydroxyurea treatment. Ten mice of each strain (5 injected with hydroxyurea, 5 uninjected controls) were used to calculate the percentage of BFU-Es killed by hydroxyurea.7 As a control, the percentage of CFU-Es killed by hydroxyurea was also measured. Friend virus sensitivity was measured by examining spleen weight 2 weeks after infection with Friend virus.