Table 3. Combined logistic regression... | American Society of Hematology

Table 3.

Combined logistic regression analysis of the association between DNA repair and NQO1 genotype and the risk of AML

Repair genotype	Detoxification genotype	Controls	Patients with AML^3-150	OR (95% CI)^3-151	P
XRCC1-399	NQO1-187
WT	WT	34	45	1^3-152	—
V	WT	71	60	0.64 (0.36-1.14)	.13
WT	V	18	18	0.74 (0.33-1.66)	.46
V	V	43	33	0.62 (0.32-1.18)	.14
XRCC3-241	NQO1-187
WT	WT	50	40	1^3-152	—
V	WT	53	57	1.47 (0.83-2.62)	.19
WT	V	36	19	0.76 (0.37-1.56)	.46
V	V	24	24	1.27 (0.62-2.63)	.51

Repair genotype	Detoxification genotype	Controls	Patients with AML^3-150	OR (95% CI)^3-151	P
XRCC1-399	NQO1-187
WT	WT	34	45	1^3-152	—
V	WT	71	60	0.64 (0.36-1.14)	.13
WT	V	18	18	0.74 (0.33-1.66)	.46
V	V	43	33	0.62 (0.32-1.18)	.14
XRCC3-241	NQO1-187
WT	WT	50	40	1^3-152	—
V	WT	53	57	1.47 (0.83-2.62)	.19
WT	V	36	19	0.76 (0.37-1.56)	.46
V	V	24	24	1.27 (0.62-2.63)	.51

WT indicates wild-type genotype; V, presence of a variant allele (either heterozygous or homozygous).

The AML group in this analysis included both de novo AML and t-AML cases.

Adjusted for age.

Used as the reference group.