Table 1. Characteristics of 328 eligible... | American Society of Hematology

Table 1.

Characteristics of 328 eligible patients, by induction treatment arm

	AD (n = 161)		ME (n = 167)
	n	%	n	%
Sex
Female	78	48	66	40
Male	83	52	101	60
Race/ethnicity
White (non-Hispanic)	141	88	149	89
Black (non-Hispanic)	11	7	12	7
Hispanic	5	3	5	3
Asian or Pacific Islander	3	2	0
Other/Unknown	1	1	1	1
Age, y
56-64	57	35	57	34
65+	104	65	110	66
AML onset
Secondary	36	22	38	23
De novo	125	78	129	77
MDR stratum
MDR+	98	61	105	63
MDR−	63	39	62	37
Performance status
0-1	125	78	127	76
2-3	36	22	40	24
WBC count
Below 10 000/μL	77	48	81	49
10 000/μL or above	84	52	86	51
FAB subtype (local)
M1	32	20	41	25
M2	59	37	48	29
M4	31	19	34	20
M5	15	9	18	11
M6	5	3	5	3
M7	3	2	0
M0	12	7	16	10
Other/unknown	4	2	5	3
CD34
Negative	51	32	42	25
Low	6	4	5	3
High	104	65	120	72
MDR-1 expression^*
Negative	64	40	65	39
Dim	19	12	16	10
Moderate	30	19	25	15
Bright	48	30	61	37
CsA-inhibited Di(OC)₂efflux^†
Negative	69	44	66	40
Dim	5	3	8	5
Moderate	24	15	22	13
Bright	59	38	69	42
CsA-inhibited Rh123 efflux^†
Negative	66	46	63	42
Dim	4	3	5	3
Moderate	26	18	20	13
Bright	47	33	61	41

	AD (n = 161)		ME (n = 167)
	n	%	n	%
Sex
Female	78	48	66	40
Male	83	52	101	60
Race/ethnicity
White (non-Hispanic)	141	88	149	89
Black (non-Hispanic)	11	7	12	7
Hispanic	5	3	5	3
Asian or Pacific Islander	3	2	0
Other/Unknown	1	1	1	1
Age, y
56-64	57	35	57	34
65+	104	65	110	66
AML onset
Secondary	36	22	38	23
De novo	125	78	129	77
MDR stratum
MDR+	98	61	105	63
MDR−	63	39	62	37
Performance status
0-1	125	78	127	76
2-3	36	22	40	24
WBC count
Below 10 000/μL	77	48	81	49
10 000/μL or above	84	52	86	51
FAB subtype (local)
M1	32	20	41	25
M2	59	37	48	29
M4	31	19	34	20
M5	15	9	18	11
M6	5	3	5	3
M7	3	2	0
M0	12	7	16	10
Other/unknown	4	2	5	3
CD34
Negative	51	32	42	25
Low	6	4	5	3
High	104	65	120	72
MDR-1 expression^*
Negative	64	40	65	39
Dim	19	12	16	10
Moderate	30	19	25	15
Bright	48	30	61	37
CsA-inhibited Di(OC)₂efflux^†
Negative	69	44	66	40
Dim	5	3	8	5
Moderate	24	15	22	13
Bright	59	38	69	42
CsA-inhibited Rh123 efflux^†
Negative	66	46	63	42
Dim	4	3	5	3
Moderate	26	18	20	13
Bright	47	33	61	41

AD indicates cytarabine/daunorubicin induction; and ME, mitoxantrone/ etoposide induction.

MDR-1 categories based on Kolmogorov-Smirnov D value: Negative D < 0.15, Dim 0.15 ≤ D < 0.20, Moderate 0.20 ≤ D < 0.30, Bright D ≥ 0.30.

Efflux categories based on Kolmogorov-Smirnov D value: Negative D < 0.20, Dim 0.20 ≤ D < 0.25, Moderate 0.25 ≤ D < 0.40, Bright D ≥ 0.40.