Genes differentially expressed in CD34+ cells from patients with high-risk MDS compared with healthy controls
| Gene . | Accession . | Map . | Description . | -fold . |
|---|---|---|---|---|
| Down-regulation | ||||
| AZU | M96326 | 19p13.3 | Azurocidin | 6 |
| CD1E | X14975 | — | CD1e antigen (major histocompatibility complex related) | 5 |
| CD8 | X13444 | 2p12 | CD8 antigen | >10 |
| CLC | L01664 | 19q13.1 | Charcot-Leyden crystal | 7 |
| CRA | U78556 | 1 | Cisplatin resistance associated | >10 |
| DHH | U59748 | 12q12 | Desert hedgehog homolog (Drosophila) | >10 |
| DYRK2 | Y09216 | 12 | Dual tyrosine-phosphorylation-regulated kinase 2 | 6 |
| GPR12 | U18548 | 13q12 | G-protein–coupled receptor 12 | 6 |
| HLF | M95585 | 17q22 | Hepatic leukemia factor | 7 |
| H-PLK | M55422 | 7 | Krueppel-related zinc finger protein | 6 |
| IFNAR1 | J03171 | 21q22.1 | Interferon alpha receptor 1 | >10 |
| MBP | Z26248 | 11 | Eosinophil granule major basic protein | >10 |
| P63 | Y16961 | 3q27-q29 | Tumor protein 63 | 5 |
| PF4 | M25897 | 4q12-q21 | Platelet factor 4 | 6 |
| PIK3CG | X83368 | 7 | Phosphatidylinositol kinase 3 catalytic gamma | 9 |
| PRKAA1 | AB022017 | 5p12 | AMP-activated protein kinase alpha 1 | 6 |
| PTCH | U59464 | 9q22.3 | Patched homolog (Drosophila) | >10 |
| STAT2 | U18671 | 12 | Signal transducer and activator of transcription 2 | 10 |
| TGB1 | M54995 | 4q12-q13 | Source: Human connective tissue activation peptide III | >10 |
| UPK3 | AF085808 | 22q13.31 | Uroplakin | >10 |
| Up-regulation | ||||
| COIL | U06632 | 17q22-q23 | Coilin | 5 |
| ELK1 | M25269 | Xp11.2 | Tyrosine kinase (oncogene) | 5 |
| HOGG1 | U88620 | 3p26.2 | Alpha-hydroxyguanine DNA glycosylase 1 (homolog) | 7 |
| MEGF3 | D87469 | 1 | Multiple epidermal growth factor-like domain 3 | 5 |
| PLC1 | AL022394 | 20q12 | Phospholipase C148 | >10 |
| PRKAR2 | X14968 | 3p21 | Protein kinase, cAMP-dependent | >10 |
| PTPRS | U35234 | 19p13.3 | Protein tyrosine phosphatase receptor S | >10 |
| SP1LZTF | AI991531 | — | SP1-like zinc finger transcription factor | >10 |
| TRAF6 | U78798 | 11 | TNF receptor-associated factor 6 | >10 |
| ZNF261 | X95808 | Xq13.1 | Zinc finger protein 261 | 9 |
| Gene . | Accession . | Map . | Description . | -fold . |
|---|---|---|---|---|
| Down-regulation | ||||
| AZU | M96326 | 19p13.3 | Azurocidin | 6 |
| CD1E | X14975 | — | CD1e antigen (major histocompatibility complex related) | 5 |
| CD8 | X13444 | 2p12 | CD8 antigen | >10 |
| CLC | L01664 | 19q13.1 | Charcot-Leyden crystal | 7 |
| CRA | U78556 | 1 | Cisplatin resistance associated | >10 |
| DHH | U59748 | 12q12 | Desert hedgehog homolog (Drosophila) | >10 |
| DYRK2 | Y09216 | 12 | Dual tyrosine-phosphorylation-regulated kinase 2 | 6 |
| GPR12 | U18548 | 13q12 | G-protein–coupled receptor 12 | 6 |
| HLF | M95585 | 17q22 | Hepatic leukemia factor | 7 |
| H-PLK | M55422 | 7 | Krueppel-related zinc finger protein | 6 |
| IFNAR1 | J03171 | 21q22.1 | Interferon alpha receptor 1 | >10 |
| MBP | Z26248 | 11 | Eosinophil granule major basic protein | >10 |
| P63 | Y16961 | 3q27-q29 | Tumor protein 63 | 5 |
| PF4 | M25897 | 4q12-q21 | Platelet factor 4 | 6 |
| PIK3CG | X83368 | 7 | Phosphatidylinositol kinase 3 catalytic gamma | 9 |
| PRKAA1 | AB022017 | 5p12 | AMP-activated protein kinase alpha 1 | 6 |
| PTCH | U59464 | 9q22.3 | Patched homolog (Drosophila) | >10 |
| STAT2 | U18671 | 12 | Signal transducer and activator of transcription 2 | 10 |
| TGB1 | M54995 | 4q12-q13 | Source: Human connective tissue activation peptide III | >10 |
| UPK3 | AF085808 | 22q13.31 | Uroplakin | >10 |
| Up-regulation | ||||
| COIL | U06632 | 17q22-q23 | Coilin | 5 |
| ELK1 | M25269 | Xp11.2 | Tyrosine kinase (oncogene) | 5 |
| HOGG1 | U88620 | 3p26.2 | Alpha-hydroxyguanine DNA glycosylase 1 (homolog) | 7 |
| MEGF3 | D87469 | 1 | Multiple epidermal growth factor-like domain 3 | 5 |
| PLC1 | AL022394 | 20q12 | Phospholipase C148 | >10 |
| PRKAR2 | X14968 | 3p21 | Protein kinase, cAMP-dependent | >10 |
| PTPRS | U35234 | 19p13.3 | Protein tyrosine phosphatase receptor S | >10 |
| SP1LZTF | AI991531 | — | SP1-like zinc finger transcription factor | >10 |
| TRAF6 | U78798 | 11 | TNF receptor-associated factor 6 | >10 |
| ZNF261 | X95808 | Xq13.1 | Zinc finger protein 261 | 9 |
These genes were selected because a greater than 5-fold difference in expression occurred when comparing CD34+ cells from marrow samples from patients with high-risk MDS versus healthy controls.
Abbreviations are explained in Table 2.