Recommendations for use of CDT and PCDT
| Factor . | Consider CDT/PCDT . | Do not use CDT/PCDT . |
|---|---|---|
| Risk of bleeding | No bleeding contraindications | Active bleeding; recent obstetrical delivery; recent (<7-14 days) major surgery, trauma, or other invasive procedure; previous hemorrhagic stroke or presence of lesions in critical locations like central nervous system; uncontrolled hypertension |
| Clinical severity | Acute limb threat (urgent) or rapidly progressive IVC thrombosis; severe symptoms/physical limitation despite initial anticoagulation | Routine first-line DVT therapy with nonthreatened limb; asymptomatic or mildly symptomatic |
| Anatomic extent | Iliofemoral DVT (higher risk for PTS and severe PTS) | DVT limited to calf, popliteal, femoral veins |
| Symptom duration | Acute: <14 days (clot likely to lyse) | Chronic: >28 days (clot will not lyse) |
| Other factors | Life expectancy >l year; walked at baseline; few comorbidities | Age >65 years; nonambulatory before the DVT; many comorbidities |
| Factor . | Consider CDT/PCDT . | Do not use CDT/PCDT . |
|---|---|---|
| Risk of bleeding | No bleeding contraindications | Active bleeding; recent obstetrical delivery; recent (<7-14 days) major surgery, trauma, or other invasive procedure; previous hemorrhagic stroke or presence of lesions in critical locations like central nervous system; uncontrolled hypertension |
| Clinical severity | Acute limb threat (urgent) or rapidly progressive IVC thrombosis; severe symptoms/physical limitation despite initial anticoagulation | Routine first-line DVT therapy with nonthreatened limb; asymptomatic or mildly symptomatic |
| Anatomic extent | Iliofemoral DVT (higher risk for PTS and severe PTS) | DVT limited to calf, popliteal, femoral veins |
| Symptom duration | Acute: <14 days (clot likely to lyse) | Chronic: >28 days (clot will not lyse) |
| Other factors | Life expectancy >l year; walked at baseline; few comorbidities | Age >65 years; nonambulatory before the DVT; many comorbidities |
IVC, inferior vena cava.