Table 1.
Treatment parameters and hematological effects of hydroxyurea therapy at the MTD in 7 cohorts of children with SCA
The average MTD values and hematological effects are similar among the studies, but more recent studies with a lower ANC toxicity threshold are associated with higher HbF responses. Mean values are reported. NA indicates not available. HUG-KIDS, Hydroxyurea Group for Kids; Toddler HUG, Toddler Hydroxyurea Group.