Risk group definitions
| Risk . | COG T-ALL risk group definitions . |
|---|---|
| Standard risk | M1 day 29 marrow; Day 29 MRD* <0.01%; CNS 1; no testicular disease; no steroid pretreatment |
| Intermediate risk | M1 or M2 day 29 marrow; day 29 MRD ≥ 0.01%; end-of-consolidation MRD < 0.1%; any CNS and testicular disease status; any steroid pretreatment status |
| Very high risk | M3 day 29 marrow or end-of-consolidation MRD ≥0.1% |
| Risk . | COG T-ALL risk group definitions . |
|---|---|
| Standard risk | M1 day 29 marrow; Day 29 MRD* <0.01%; CNS 1; no testicular disease; no steroid pretreatment |
| Intermediate risk | M1 or M2 day 29 marrow; day 29 MRD ≥ 0.01%; end-of-consolidation MRD < 0.1%; any CNS and testicular disease status; any steroid pretreatment status |
| Very high risk | M3 day 29 marrow or end-of-consolidation MRD ≥0.1% |
M1 marrow, less than 5% blasts; M2 marrow, 5-25% blasts; M3 marrow, more than 25% blasts by morphology; CNS1, less than 5 WBC/µL and no blasts in the CSF.
Central flow cytometry-based MRD.