| Hemoglobin ≤10 g/dL on basis of disease |
| Platelet count <100 K/μL on basis of disease |
| Constitutional symptoms in setting of disease progression |
| Symptomatic hyperviscosity |
| Moderate/severe peripheral neuropathy |
| Symptomatic extramedullary disease (lymphadenopathy, hepatosplenomegaly, renal involvement, pleural effusions, Bing-Neel syndrome, etc) |
| Symptomatic cryoglobulins, cold agglutinins, amyloidosis |
| Hemoglobin ≤10 g/dL on basis of disease |
| Platelet count <100 K/μL on basis of disease |
| Constitutional symptoms in setting of disease progression |
| Symptomatic hyperviscosity |
| Moderate/severe peripheral neuropathy |
| Symptomatic extramedullary disease (lymphadenopathy, hepatosplenomegaly, renal involvement, pleural effusions, Bing-Neel syndrome, etc) |
| Symptomatic cryoglobulins, cold agglutinins, amyloidosis |