Novel alternative hemostatic agents for hemophilia
| 1. Coagulation factor mutants or mimics |
| • Bispecific antibody mimicking FVIII |
| • Super factor Va |
| • Zymogen-like factor Xa variant |
| • PACE/furin cleaved FVIII |
| 2. Natural anticoagulant knock-down or disruption |
| • RNA targeting antithrombin |
| • TFPI |
| • APC-specific serpin |
| 1. Coagulation factor mutants or mimics |
| • Bispecific antibody mimicking FVIII |
| • Super factor Va |
| • Zymogen-like factor Xa variant |
| • PACE/furin cleaved FVIII |
| 2. Natural anticoagulant knock-down or disruption |
| • RNA targeting antithrombin |
| • TFPI |
| • APC-specific serpin |