Comparison of FFP and 4-factor PCCs
| . | FFP . | 4-Factor PCCs* . |
|---|---|---|
| Coagulation factor contained | All | FII, FVII, FIX, and FX (in all preparations); PC, PS, antithrombin (in some preparations) |
| ABO typing | Required | Not required |
| Preparation time | 30-60 min (requires thawing) | Minutes (reconstitution of lyophilized powder) |
| Administration time | Hours | 15 min per 2000 IU |
| Initial effective volume | 1000 mL | ∼40 mL |
| Duration of action | ∼6 h (dependent on half-life of coagulation factors) | ∼6 h (dependent on half-life of coagulation factors) |
| Virus inactivated | No | Yes |
| . | FFP . | 4-Factor PCCs* . |
|---|---|---|
| Coagulation factor contained | All | FII, FVII, FIX, and FX (in all preparations); PC, PS, antithrombin (in some preparations) |
| ABO typing | Required | Not required |
| Preparation time | 30-60 min (requires thawing) | Minutes (reconstitution of lyophilized powder) |
| Administration time | Hours | 15 min per 2000 IU |
| Initial effective volume | 1000 mL | ∼40 mL |
| Duration of action | ∼6 h (dependent on half-life of coagulation factors) | ∼6 h (dependent on half-life of coagulation factors) |
| Virus inactivated | No | Yes |
IU, international units; PC, protein C; PS, protein S.
Beriplex N/P/Kcentra (CSL Behring), Cofact (Sanquin), Kaskadil (LFB), Octaplex (Octapharma), and Prothromplex T(otal) (Baxter).