Basic characteristics of 2 CML-specific PRO instruments
| Questionnaire . | Construct being measured . | Overall number of items . | Specific domains measured . | Scoring and interpretation . |
|---|---|---|---|---|
| EORTC QLQ-CML2430 (to be used in conjunction with the EORTC QLQ-C30) | QoL in patients with CML | 54 (including the EORTC QLQ-C30) | Impact on daily life; impact on worry/mood; body-image problems; symptom burden (abdominal pain or cramps, dry mouth, skin problems, headache, aches in muscles or joints, hair loss, sweating excessively, heartburn, drowsiness, swelling/edema, urinate frequently, problems with eyes, muscle cramps); satisfaction with care and information; and satisfaction with social life | Score ranges between 0 and 100 for all scales, with higher scores indicating worse outcomes, except for satisfaction with care and information and satisfaction with social life, where higher scores indicate better outcome |
| MDASI CML31 | Symptom burden in patients with CML | 26 | Symptom severity (pain, fatigue, nausea, sleep, distress, shortness of breath, lack of appetite, drowsiness, dry mouth, sadness, vomiting, difficulty numbness/tingling, edema, rush, muscle soreness or cramping, bruising, malaise, headache); impact of symptoms on daily functioning | Score ranges between 0 and 10, with higher scores indicating increased symptom burden |
| Questionnaire . | Construct being measured . | Overall number of items . | Specific domains measured . | Scoring and interpretation . |
|---|---|---|---|---|
| EORTC QLQ-CML2430 (to be used in conjunction with the EORTC QLQ-C30) | QoL in patients with CML | 54 (including the EORTC QLQ-C30) | Impact on daily life; impact on worry/mood; body-image problems; symptom burden (abdominal pain or cramps, dry mouth, skin problems, headache, aches in muscles or joints, hair loss, sweating excessively, heartburn, drowsiness, swelling/edema, urinate frequently, problems with eyes, muscle cramps); satisfaction with care and information; and satisfaction with social life | Score ranges between 0 and 100 for all scales, with higher scores indicating worse outcomes, except for satisfaction with care and information and satisfaction with social life, where higher scores indicate better outcome |
| MDASI CML31 | Symptom burden in patients with CML | 26 | Symptom severity (pain, fatigue, nausea, sleep, distress, shortness of breath, lack of appetite, drowsiness, dry mouth, sadness, vomiting, difficulty numbness/tingling, edema, rush, muscle soreness or cramping, bruising, malaise, headache); impact of symptoms on daily functioning | Score ranges between 0 and 10, with higher scores indicating increased symptom burden |
EORTC QLQ-CML24, European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Chronic Myeloid Leukemia 24; EORTC QLQ-C30, European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30; MDASI-CML, MD Anderson Symptom Inventory Chronic Myeloid Leukemia Module.