Table 1. Outcomes of contemporary... | American Society of Hematology

Table 1.

Outcomes of contemporary pediatric protocols

Trial	No. of patients	Years of recruitment	Age, y	Overall survival, %	Event-free survival, %	Toxicity			Relapse risk, %
Trial	No. of patients	Years of recruitment	Age, y	Overall survival, %	Event-free survival, %	Induction death, %	Death in remission, %	Proportion of patients with at least 1 serious adverse event, %	Relapse risk, %
UKALL2003¹⁵	3126	October 2003 to June 2011	1-24	89 at 5 y	87 at 5 y	1.5	2.3	37.2 (30.6 ages 1-9 y)	8.8 at 5 y
IC-BFM 2002⁴²	5060	November 2002 to November 2007	1-17	82 at 5 y	74 at 5 y	2.8	5.3	—	19 at 5 y
NOPHO ALL2008⁴	1162	July 2008 to April 2013	1-45	—	88 ages 1-9 y, 79 ages 10-17 y, 73 ages 18-45 y at 5 y	1.1	3.3	49.8 (44.5 ages 1-9 y)	8.2 at median 4 y
St. Jude’s Total Therapy XV⁴³	498	June 2000 to October 2007	1-18	93 at 10 y	86 at 10 y	—	2.3	—	11.6 at 10 y
DFCI 05-001⁴⁴	551	April 2005 to February 2010	1-18	91 at 5 y	85 at 5 y	2.0	—	—	8.9
DCOG 9⁴⁵	859	January 1997 to November 2004	1-18	86 at 5 y	81 at 5 y	1.0	2.7	—	15.8
COG²	21626	January 1990 to December 2005	0-22	90 at 5 y	—	—	1.6	—	Death after relapse 7.22 at 5 y

Trial	No. of patients	Years of recruitment	Age, y	Overall survival, %	Event-free survival, %	Toxicity			Relapse risk, %
Trial	No. of patients	Years of recruitment	Age, y	Overall survival, %	Event-free survival, %	Induction death, %	Death in remission, %	Proportion of patients with at least 1 serious adverse event, %	Relapse risk, %
UKALL2003¹⁵	3126	October 2003 to June 2011	1-24	89 at 5 y	87 at 5 y	1.5	2.3	37.2 (30.6 ages 1-9 y)	8.8 at 5 y
IC-BFM 2002⁴²	5060	November 2002 to November 2007	1-17	82 at 5 y	74 at 5 y	2.8	5.3	—	19 at 5 y
NOPHO ALL2008⁴	1162	July 2008 to April 2013	1-45	—	88 ages 1-9 y, 79 ages 10-17 y, 73 ages 18-45 y at 5 y	1.1	3.3	49.8 (44.5 ages 1-9 y)	8.2 at median 4 y
St. Jude’s Total Therapy XV⁴³	498	June 2000 to October 2007	1-18	93 at 10 y	86 at 10 y	—	2.3	—	11.6 at 10 y
DFCI 05-001⁴⁴	551	April 2005 to February 2010	1-18	91 at 5 y	85 at 5 y	2.0	—	—	8.9
DCOG 9⁴⁵	859	January 1997 to November 2004	1-18	86 at 5 y	81 at 5 y	1.0	2.7	—	15.8
COG²	21626	January 1990 to December 2005	0-22	90 at 5 y	—	—	1.6	—	Death after relapse 7.22 at 5 y

COG, Children's Oncology Group; DCOG, Dutch Childhood Oncology Group; DFCI, Dana-Farber Cancer Institute; IC-BFM, International Berlin-Frankfurt-Münster Study Group; NOPHO, Nordic Society of Paediatric Haematolgy and Oncology.

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