Table 1.

Laboratory evaluation of thrombocytopenia in pregnancy

EvaluationTests
Recommended tests Complete blood count 
Peripheral blood smear review 
Direct antiglobulin (Coombs) test (DAT) 
Reticulocyte count 
Liver function tests 
Viral screen (HIV, HCV, HBV, CMV) 
Creatinine 
Consider testing Antinuclear antibody 
Antiphospholipid antibodies, lupus anticoagulant 
Thyroid function tests 
Helicobacter pylori (stool antigen or breath test) 
Coagulation testing 
Quantitative immunoglobulins 
VWD panel (for VWF type 2b) 
ADAMTS-13 level 
Not routinely recommended Antiplatelet antibody 
Bone marrow aspiration 
Peripheral blood flow cytometry 
Thrombopoietin level 
EvaluationTests
Recommended tests Complete blood count 
Peripheral blood smear review 
Direct antiglobulin (Coombs) test (DAT) 
Reticulocyte count 
Liver function tests 
Viral screen (HIV, HCV, HBV, CMV) 
Creatinine 
Consider testing Antinuclear antibody 
Antiphospholipid antibodies, lupus anticoagulant 
Thyroid function tests 
Helicobacter pylori (stool antigen or breath test) 
Coagulation testing 
Quantitative immunoglobulins 
VWD panel (for VWF type 2b) 
ADAMTS-13 level 
Not routinely recommended Antiplatelet antibody 
Bone marrow aspiration 
Peripheral blood flow cytometry 
Thrombopoietin level 

CMV, cytomegalovirus; HBV, hepatitis B virus; HCV, hepatitis C virus.

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