Clinical signs and symptoms of APL
| Historical and examination findings |
| Bleeding symptoms—gingival bleeding, epistaxis, bruising, menorrhagia |
| Central nervous system bleeding symptoms—headache, visual changes, neurologic deficits |
| Constitutional symptoms—weakness, fatigue |
| Examination findings—Multiple ecchymoses, petechiae, excessive bruising or bleeding at venipuncture sites |
| Laboratory findings |
| Blood count—anemia, thrombocytopenia (potentially severe), and typically leukopenia (leukocytosis also occurs) |
| Coagulation—prolonged PT and/or PTT, decreased fibrinogen, and/or elevated d-dimer |
| Peripheral smear—promyelocytes characterized by abundant azurophilic granules and potentially with multiple Auer rods, or with a bilobed or reniform nuclear contour without apparent granules |
| Historical and examination findings |
| Bleeding symptoms—gingival bleeding, epistaxis, bruising, menorrhagia |
| Central nervous system bleeding symptoms—headache, visual changes, neurologic deficits |
| Constitutional symptoms—weakness, fatigue |
| Examination findings—Multiple ecchymoses, petechiae, excessive bruising or bleeding at venipuncture sites |
| Laboratory findings |
| Blood count—anemia, thrombocytopenia (potentially severe), and typically leukopenia (leukocytosis also occurs) |
| Coagulation—prolonged PT and/or PTT, decreased fibrinogen, and/or elevated d-dimer |
| Peripheral smear—promyelocytes characterized by abundant azurophilic granules and potentially with multiple Auer rods, or with a bilobed or reniform nuclear contour without apparent granules |