Issues with the management of older ALL patients
| Issues |
| Poorer results in older ALL patients Negative perception of cure rates by physicians |
| Less recruitment into clinical trials |
| Limited biological studies |
| Lack of prospective clinical trials |
| Heterogeneity of patient characteristics |
| Increase of poor prognostic features |
| Higher mortality and morbidity from chemotherapy |
| Variety of dose reductions and low time/dose intensity |
| Issues |
| Poorer results in older ALL patients Negative perception of cure rates by physicians |
| Less recruitment into clinical trials |
| Limited biological studies |
| Lack of prospective clinical trials |
| Heterogeneity of patient characteristics |
| Increase of poor prognostic features |
| Higher mortality and morbidity from chemotherapy |
| Variety of dose reductions and low time/dose intensity |