Absolute VTE risk in pregnancy and postpartum in asymptomatic women with inherited thrombophilia with and without a family history
| Inherited thrombophilia . | Family history of VTE* . | Combined antepartum and postpartum risk (%) . | 95% CI . |
|---|---|---|---|
| FVL | |||
| Heterozygous | No | 1.2 | 0.8-1.8 |
| Heterozygous | Yes | 3.1 | 2.1-4.6 |
| Homozygous | No | 4.8 | 1.4-16.8 |
| Homozygous | Yes | 14.0 | 6.3-25.8 |
| PGM | |||
| Heterozygous | No | 1.0 | 0.3-2.6 |
| Heterozygous | Yes | 2.6 | 0.9-5.6 |
| Homozygous | No | 3.7 | 0.2-78.3 |
| Homozygous | Yes | — | |
| Compound FVL/PGM† | 5.5 | 0-21.92 | |
| PC deficiency | |||
| No | 0.7 | 0.3-1.5 | |
| Yes | 1.7 | 0.4-8.9 | |
| 0 | 0-25.9 (total) | ||
| 0 | 0-79.4 (no prophylaxis) | ||
| PS deficiency | |||
| No | 0.5 | 0.2-1.0 | |
| Yes | 6.6 | 2.2-14.7 | |
| 0 | 0-32.4 (total) | ||
| 0 | 0-48.9 (no prophylaxis) | ||
| AT deficiency | |||
| No | 0.7 | 0.2-2.4 | |
| Yes | 3.0 | 0.08-15.8 | |
| 8.3 | 1.4-35.4 (total) | ||
| 14.3 | 2.6-51.3 (no prophylaxis) |
| Inherited thrombophilia . | Family history of VTE* . | Combined antepartum and postpartum risk (%) . | 95% CI . |
|---|---|---|---|
| FVL | |||
| Heterozygous | No | 1.2 | 0.8-1.8 |
| Heterozygous | Yes | 3.1 | 2.1-4.6 |
| Homozygous | No | 4.8 | 1.4-16.8 |
| Homozygous | Yes | 14.0 | 6.3-25.8 |
| PGM | |||
| Heterozygous | No | 1.0 | 0.3-2.6 |
| Heterozygous | Yes | 2.6 | 0.9-5.6 |
| Homozygous | No | 3.7 | 0.2-78.3 |
| Homozygous | Yes | — | |
| Compound FVL/PGM† | 5.5 | 0-21.92 | |
| PC deficiency | |||
| No | 0.7 | 0.3-1.5 | |
| Yes | 1.7 | 0.4-8.9 | |
| 0 | 0-25.9 (total) | ||
| 0 | 0-79.4 (no prophylaxis) | ||
| PS deficiency | |||
| No | 0.5 | 0.2-1.0 | |
| Yes | 6.6 | 2.2-14.7 | |
| 0 | 0-32.4 (total) | ||
| 0 | 0-48.9 (no prophylaxis) | ||
| AT deficiency | |||
| No | 0.7 | 0.2-2.4 | |
| Yes | 3.0 | 0.08-15.8 | |
| 8.3 | 1.4-35.4 (total) | ||
| 14.3 | 2.6-51.3 (no prophylaxis) |
Table adapted from Bates et al11 with calculated risk based on a baseline VTE incidence of 1.4 per 1000 pregnancies from a non–family-based population study.70 The antepartum and postpartum risks are roughly equal (half the total events occurring antepartum and half postpartum).6,20,26,27 Certain thrombophilias such as heterozygous FVL, heterozygous PGM, and PS deficiency have a higher VTE risk reported in the postpartum period.19,23,25,28,71
The definition of family history varies according to each study.
Based on data from Gerhardt et al,17 which includes a population with and without family history of VTE.