Table 5.

Criteria for “high-risk pregnancy” in a woman with PV or ET

High-risk pregnancy criteria for PV or ET
Sustained rise in platelet count to >1500 × 109/L 
Previous venous or arterial thrombosis 
Previous hemorrhage attributed to the underlying PV or ET 
Previous pregnancy complication, including any of the following: 
 • ≥1 unexplained deaths of a morphologically normal fetus ≥10 wk of gestation 
 • ≥1 premature delivery of a morphologically normal fetus <34 wk gestation because of: 
   (i) Severe preeclampsia or eclampsia defined according to standard definitions 
   (ii) Recognized features of placental insufficiency 
 • ≥3 consecutive otherwise unexplained miscarriages <10 wk gestation, 
 • Otherwise unexplained intrauterine growth restriction 
 • Significant antepartum or postpartum hemorrhage requiring transfusion 
 • Abnormal uterine artery Doppler at 20 wk (mean pulsatility index >1.4) 
High-risk pregnancy criteria for PV or ET
Sustained rise in platelet count to >1500 × 109/L 
Previous venous or arterial thrombosis 
Previous hemorrhage attributed to the underlying PV or ET 
Previous pregnancy complication, including any of the following: 
 • ≥1 unexplained deaths of a morphologically normal fetus ≥10 wk of gestation 
 • ≥1 premature delivery of a morphologically normal fetus <34 wk gestation because of: 
   (i) Severe preeclampsia or eclampsia defined according to standard definitions 
   (ii) Recognized features of placental insufficiency 
 • ≥3 consecutive otherwise unexplained miscarriages <10 wk gestation, 
 • Otherwise unexplained intrauterine growth restriction 
 • Significant antepartum or postpartum hemorrhage requiring transfusion 
 • Abnormal uterine artery Doppler at 20 wk (mean pulsatility index >1.4) 

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