Diagnostic criteria for PPV-MF and PET MF: IWG-MRT criteria
| IWG-MRT criteria . | PPV-MF . | PET-MF . |
|---|---|---|
| Required | 1. Documentation of a previous diagnosis of PV as defined by the WHO criteria 2. BM fibrosis grade 2-3 (on 0-3 scale) or grade 3-4 (on 0-4 scale)|| | 1. Documentation of a previous diagnosis of ET as defined by the WHO criteria 2. BM fibrosis grade 2-3 (on 0-3 scale) or grade 3-4 (on 0-4 scale)|| |
| Additional | 1. Anemia¶ or sustained loss of requirement of either phlebotomy (in the absence of cytoreductive therapy) or cytoreductive treatment of erythrocytosis 2. A leukoerythroblastic peripheral blood picture 3. Increasing splenomegaly defined as either an increase in palpable splenomegaly of ≥5 cm (distance of the tip of the spleen from the left costal margin) or the appearance of a newly palpable splenomegaly 4. Development of ≥1 of 3 constitutional symptoms: >10% weight loss in 6 mo, night sweats, unexplained fever (>37.5°C) | 1. Anemia¶ and a ≥2 mg/mL decrease from baseline Hb level 2. A leukoerythroblastic peripheral blood picture 3. Increasing splenomegaly defined as either an increase in palpable splenomegaly of ≥5 cm (distance of the tip of the spleen from the left costal margin) or the appearance of a newly palpable splenomegaly 4. Increased LDH (above reference level) 5. Development of ≥1 of 3 constitutional symptoms: >10% weight loss in 6 mo, night sweats, unexplained fever (>37.5°C) |
| Criteria required for diagnosis | All 2 required criteria and at least 2 additional criterion | All 2 required criteria and at least 2 additional criterion |
| IWG-MRT criteria . | PPV-MF . | PET-MF . |
|---|---|---|
| Required | 1. Documentation of a previous diagnosis of PV as defined by the WHO criteria 2. BM fibrosis grade 2-3 (on 0-3 scale) or grade 3-4 (on 0-4 scale)|| | 1. Documentation of a previous diagnosis of ET as defined by the WHO criteria 2. BM fibrosis grade 2-3 (on 0-3 scale) or grade 3-4 (on 0-4 scale)|| |
| Additional | 1. Anemia¶ or sustained loss of requirement of either phlebotomy (in the absence of cytoreductive therapy) or cytoreductive treatment of erythrocytosis 2. A leukoerythroblastic peripheral blood picture 3. Increasing splenomegaly defined as either an increase in palpable splenomegaly of ≥5 cm (distance of the tip of the spleen from the left costal margin) or the appearance of a newly palpable splenomegaly 4. Development of ≥1 of 3 constitutional symptoms: >10% weight loss in 6 mo, night sweats, unexplained fever (>37.5°C) | 1. Anemia¶ and a ≥2 mg/mL decrease from baseline Hb level 2. A leukoerythroblastic peripheral blood picture 3. Increasing splenomegaly defined as either an increase in palpable splenomegaly of ≥5 cm (distance of the tip of the spleen from the left costal margin) or the appearance of a newly palpable splenomegaly 4. Increased LDH (above reference level) 5. Development of ≥1 of 3 constitutional symptoms: >10% weight loss in 6 mo, night sweats, unexplained fever (>37.5°C) |
| Criteria required for diagnosis | All 2 required criteria and at least 2 additional criterion | All 2 required criteria and at least 2 additional criterion |