Systems involved in patients with an IBMFS following SCT
| System . | FA . | DC . | DBA . | SDS . |
|---|---|---|---|---|
| General | Chronic GVHD | Chronic GVHD | Chronic GVHD | Chronic GVHD |
| Oncology | Head and neck SCC (tongue), vulvar SCC, PTLD, skin | Head and neck SCC (tongue), anogenital SCC, PTLD, skin | Colon, lung, stomach, osteosarcoma | |
| Skin | Basal cell carcinoma and SCC | Basal cell carcinoma and SCC | ||
| Skeletal | Osteopenia and osteoporosis | Osteopenia and osteoporosis | ||
| Eyes | Cataracts, dry eyes, retinitis, blepharitis | Cataracts, lacrimal duct stenosis | Cataracts | |
| Gonads, male | Infertility | Infertility | Infertility | Infertility |
| Gonads, female | Infertility, early menopause | Infertility, early menopause | Infertility, early menopause | Infertility, early menopause |
| Otology | Sensory hearing loss | |||
| Cardiology | Iron overload | Iron overload, hyperlipidemia | Iron overload | |
| Endocrine | Diabetes, growth hormone deficiency, hypothyroid, dyslipidemia | Hypogonadism, dyslipidemia | ||
| Gastroenterology | Poor eating | Rectal adenocarcinoma | Stomach and colon cancer | |
| Liver | Cirrhosis, fibrosis, elevated enzymes, iron overload, adenoma, hepatocellular carcinoma | Cirrhosis, fibrosis, hepatopulmonary syndrome, portal hypertension, iron overload, hepatocellular carcinoma | Iron overload | |
| Dental | Oral SCC | Oral SCC | ||
| ENT | Head and neck SCC | Head and neck SCC | ||
| Immunology | Slow immune reconstitution | Slow immune reconstitution | Slow immune reconstitution | Slow immune reconstitution |
| Lung | Bronchiolitis obliterans | Pulmonary fibrosis, pulmonary arteriovenous malformations | ||
| Vascular complications | Telangiectases and arteriovenous malformations | |||
| Psychiatry | Psychosocial issues | Psychosocial issues | Psychosocial issues | Psychosocial issues |
| Diagnostic test after SCT | Increased chromosome breakage with DEB or MMC, need to use skin fibroblasts | Genotype with nonhematopoietic tissue | Genotype with nonhematopoietic tissue | Decreased pancreatic enzymes (trypsinogen, isoamylase), genotype with nonhematopoietic tissue |
| System . | FA . | DC . | DBA . | SDS . |
|---|---|---|---|---|
| General | Chronic GVHD | Chronic GVHD | Chronic GVHD | Chronic GVHD |
| Oncology | Head and neck SCC (tongue), vulvar SCC, PTLD, skin | Head and neck SCC (tongue), anogenital SCC, PTLD, skin | Colon, lung, stomach, osteosarcoma | |
| Skin | Basal cell carcinoma and SCC | Basal cell carcinoma and SCC | ||
| Skeletal | Osteopenia and osteoporosis | Osteopenia and osteoporosis | ||
| Eyes | Cataracts, dry eyes, retinitis, blepharitis | Cataracts, lacrimal duct stenosis | Cataracts | |
| Gonads, male | Infertility | Infertility | Infertility | Infertility |
| Gonads, female | Infertility, early menopause | Infertility, early menopause | Infertility, early menopause | Infertility, early menopause |
| Otology | Sensory hearing loss | |||
| Cardiology | Iron overload | Iron overload, hyperlipidemia | Iron overload | |
| Endocrine | Diabetes, growth hormone deficiency, hypothyroid, dyslipidemia | Hypogonadism, dyslipidemia | ||
| Gastroenterology | Poor eating | Rectal adenocarcinoma | Stomach and colon cancer | |
| Liver | Cirrhosis, fibrosis, elevated enzymes, iron overload, adenoma, hepatocellular carcinoma | Cirrhosis, fibrosis, hepatopulmonary syndrome, portal hypertension, iron overload, hepatocellular carcinoma | Iron overload | |
| Dental | Oral SCC | Oral SCC | ||
| ENT | Head and neck SCC | Head and neck SCC | ||
| Immunology | Slow immune reconstitution | Slow immune reconstitution | Slow immune reconstitution | Slow immune reconstitution |
| Lung | Bronchiolitis obliterans | Pulmonary fibrosis, pulmonary arteriovenous malformations | ||
| Vascular complications | Telangiectases and arteriovenous malformations | |||
| Psychiatry | Psychosocial issues | Psychosocial issues | Psychosocial issues | Psychosocial issues |
| Diagnostic test after SCT | Increased chromosome breakage with DEB or MMC, need to use skin fibroblasts | Genotype with nonhematopoietic tissue | Genotype with nonhematopoietic tissue | Decreased pancreatic enzymes (trypsinogen, isoamylase), genotype with nonhematopoietic tissue |
Systems listed are those that have been reported in the literature or that are plausible.11,21,42 Many of these may be associated with aging per se, but have been reported to be worse following SCT.
PTLD, posttransplant lymphoproliferative disease.