Table 3. Pharmacologics/dietary... | American Society of Hematology

Table 3.

Pharmacologics/dietary supplements targeting pain mechanisms tested in mice and/or patients with sickle cell disease

Generic name	Mechanistic target	Action	Sickle subjects
Generic name	Mechanistic target	Action	Mice	Humans
A-425619	TRPV1	Antagonist	X
AT-200	NOP/R and MOR	Agonist	X
Bosentan	ET-A and ET-B receptors	Antagonist	X	X
Coenzyme Q10	Oxidative stress	Inhibitor	X	X
CP55940	CB1R and CB2R	Agonist	X
Crizanlizumab	P-selectin	Antibody		X
Cromolyn	Mast cell	Stabilizer	X	X
Curcumin	ROS	Inhibitor	X	X
Duloxetine	Serotonin and norepinephrine reuptake transporter	Inhibitor	X	X
HC-030031	TRPA1	Antagonist	X
Imatinib	Mast cell/c-kit/RTK	Inhibitor	X	X
KN-93	CaMKII	Inhibitor	X
l-arginine	NOS	Substrate		X
l-glutamine	Oxidative stress	Antioxidant		X
Lovastatin	HMG-CoA reductase	Inhibitor	X
PEG-ADA	Adenosine	Inhibitor	X
Rapamycin	mTOR	Inhibitor	X
Rapamycin	HbF	Inducer	X
Simvastatin	HMG-CoA reductase, calpain-1	Inhibitor	X	X
Sivelestat	Neutrophil elastase	Inhibitor	X
TAK-242	TLR4	Inhibitor	X
Trifluoperazine	CaMKIIα	Inhibitor	X	X
ω-3 fatty acid	Oxidative stress	Antioxidant	X	X

Generic name	Mechanistic target	Action	Sickle subjects
Generic name	Mechanistic target	Action	Mice	Humans
A-425619	TRPV1	Antagonist	X
AT-200	NOP/R and MOR	Agonist	X
Bosentan	ET-A and ET-B receptors	Antagonist	X	X
Coenzyme Q10	Oxidative stress	Inhibitor	X	X
CP55940	CB1R and CB2R	Agonist	X
Crizanlizumab	P-selectin	Antibody		X
Cromolyn	Mast cell	Stabilizer	X	X
Curcumin	ROS	Inhibitor	X	X
Duloxetine	Serotonin and norepinephrine reuptake transporter	Inhibitor	X	X
HC-030031	TRPA1	Antagonist	X
Imatinib	Mast cell/c-kit/RTK	Inhibitor	X	X
KN-93	CaMKII	Inhibitor	X
l-arginine	NOS	Substrate		X
l-glutamine	Oxidative stress	Antioxidant		X
Lovastatin	HMG-CoA reductase	Inhibitor	X
PEG-ADA	Adenosine	Inhibitor	X
Rapamycin	mTOR	Inhibitor	X
Rapamycin	HbF	Inducer	X
Simvastatin	HMG-CoA reductase, calpain-1	Inhibitor	X	X
Sivelestat	Neutrophil elastase	Inhibitor	X
TAK-242	TLR4	Inhibitor	X
Trifluoperazine	CaMKIIα	Inhibitor	X	X
ω-3 fatty acid	Oxidative stress	Antioxidant	X	X

ET_A and ET_B, endothelin A and endothelin B; CB1R/CB2R, cannabinoid receptor 1/2; HMG-CoA reductase, 3-hydroxy-3-methyl-glutaryl–coenzyme reductase; NE, norepinephrine; NOS, nitric oxide synthase; PEG-ADA, polyethylene glycol–modified adenosine deaminase; TRPA1, transient receptor potential cation channel subfamily A, member 1.

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